Radiochemistry for positron emission tomography

J Rong, A Haider, TE Jeppesen, L Josephson… - Nature …, 2023 - nature.com
Positron emission tomography (PET) constitutes a functional imaging technique that is
harnessed to probe biological processes in vivo. PET imaging has been used to diagnose …

Good practices for 68Ga radiopharmaceutical production

BJB Nelson, JD Andersson, F Wuest… - EJNMMI …, 2022 - Springer
Abstract Background The radiometal gallium-68 (68Ga) is increasingly used in diagnostic
positron emission tomography (PET), with 68Ga-labeled radiopharmaceuticals developed …

Production review of accelerator-based medical isotopes

Y Wang, D Chen, R dos Santos Augusto, J Liang, Z Qin… - Molecules, 2022 - mdpi.com
The production of reactor-based medical isotopes is fragile, which has meant supply
shortages from time to time. This paper reviews alternative production methods in the form of …

Multi-curie production of gallium-68 on a biomedical cyclotron and automated radiolabelling of PSMA-11 and DOTATATE

H Thisgaard, J Kumlin, N Langkjær, J Chua… - EJNMMI radiopharmacy …, 2021 - Springer
Background With increasing clinical demand for gallium-68, commercial germanium-
68/gallium-68 ([68 Ge] Ge/[68 Ga] Ga) generators are incapable of supplying sufficient …

Recent Breakthrough in 68Ga-Radiopharmaceuticals Cold Kits for Convenient PET Radiopharmacy

D Satpati - Bioconjugate Chemistry, 2021 - ACS Publications
68Ga-PET has emerged as an important diagnostic tool for precise detection and monitoring
of oncological situations. Availability, cost, and radiosynthesis procedure are determining …

Comparing the clinical performance and cost efficacy of [68Ga]Ga-PSMA-11 and [18F]PSMA-1007 in the diagnosis of recurrent prostate cancer: a Markov chain …

I Alberts, C Mingels, HD Zacho, S Lanz… - European journal of …, 2021 - Springer
Abstract Purpose Amongst others,[68 Ga] Ga-PSMA-11 and [18 F] PSMA-1007 are available
for the detection of recurrent prostate cancer (rPC). There are currently limited data …

[HTML][HTML] Advancement in production of radiotracers

SB Hansen, D Bender - Seminars in nuclear medicine, 2022 - Elsevier
After introduction of the first commercial combined PET and CT scanner in 2001, this
diagnostic tool quickly became a clinical success and was considered the fastest growing …

High-yield cyclotron production of 203Pb using a sealed 205Tl solid target

BJB Nelson, J Wilson, MK Schultz… - Nuclear medicine and …, 2023 - Elsevier
Abstract Introduction 203 Pb (t 1/2= 51.9 h, 279 keV (81%)) is a diagnostic SPECT imaging
radionuclide ideally suited for theranostic applications in combination with 212 Pb for …

Radiosynthesis of [18F]SiFAlin-TATE for clinical neuroendocrine tumor positron emission tomography

S Lindner, C Wängler, JJ Bailey, K Jurkschat… - Nature …, 2020 - nature.com
Here, we describe an extension of our silicon fluoride acceptor (SiFA) protocol for 18F-
labeling of peptides that addresses challenges associated with preparing a clinical-grade …

Recent Advances in the Clinical Translation of Silicon Fluoride Acceptor (SiFA) 18F-Radiopharmaceuticals

L Gower-Fry, T Kronemann, A Dorian, Y Pu… - Pharmaceuticals, 2021 - mdpi.com
The incorporation of silicon fluoride acceptor (SiFA) moieties into a variety of molecules,
such as peptides, proteins and biologically relevant small molecules, has improved the …