Aging is accompanied by remodeling of the immune system. With time, this leads to a
decline in immune efficacy, resulting in increased vulnerability to infectious diseases …

For more than two decades, sepsis was defined as a microbial infection that produces fever
(or hypothermia), tachycardia, tachypnoea and blood leukocyte changes. Sepsis is now …

Sepsis occurs when an infection exceeds local tissue containment and induces a series of
dysregulated physiologic responses that result in organ dysfunction. A subset of patients …

Sepsis is a life-threatening condition and a global disease burden. Today, the
heterogeneous syndrome is defined as severe organ dysfunction caused by a dysregulated …

Human aging is a multifactorial phenomenon that affects numerous organ systems and
cellular processes, with the immune system being one of the most dysregulated …

BACKGROUND. A defining pathophysiologic feature of sepsis is profound apoptosis-
induced death and depletion of CD4+ and CD8+ T cells. Interleukin-7 (IL-7) is an …

Sepsis is a systemic inflammatory response induced by an infection, leading to organ
dysfunction and mortality. Historically, sepsis-induced organ dysfunction and lethality were …

Following periods of haematopoietic cell stress, such as after chemotherapy, radiotherapy,
infection and transplantation, patient outcomes are linked to the degree of immune …

The morbidity and mortality of HIV type-1 (HIV-1)-related diseases were dramatically
diminished by the grounds of the introduction of potent antiretroviral therapy, which induces …

Sepsis—which is a severe life-threatening infection with organ dysfunction—initiates a
complex interplay of host pro-inflammatory and anti-inflammatory processes. Sepsis can be …