The development of novel synthetic strategies to form new chemical entities in a
stereoselective manner is an ongoing significant objective in organic and medicinal …

Asymmetric catalytic multicomponent cascade reactions have become indispensable tools
for enantioselective construction of spirooxindoles. In recent years, a number of successful …

The enantioselective synthesis of spirocycles has long been pursued by organic chemists.
Despite their unique 3D properties and presence in several natural products, the difficulty in …

Chiral spirooxindoles are privileged heterocyclic motifs, which are widely found in natural
alkaloids and pharmaceuticals. Moreover, the construction of chiral spiro-cyclic frameworks …

Cycloaddition reactions are among the most important tools for the construction of cyclic
compounds in organic synthesis, since these reactions are vital to access natural products …

A copper-catalyzed umpolung of N-2, 2, 2-trifluoroethylisatin ketimines for the
enantioselective 1, 3-dipolar cycloaddition with benzo [b] thiophene sulfones was …

Spirocyclic pyrrolidines are structural motifs frequently found in a wide variety of natural
products, pharmaceuticals and biologically significant compounds. In the past few years …

An axially chiral styrene-based organocatalyst, featuring a combination of axially chiral
styrene-based structure and a pyrrole ring, has been designed and synthesized. This …

The new millennium has witnessed the rapid development of synthetic organofluorine
chemistry all over the world, and chemists in China have made significant contributions in …

Bifunctional squaramides as a branch of organo‐catalysts showed powerful strategies in the
art of asymmetric synthesis, and they have been proved to be highly efficient and versatile …