Inwardly rectifying K+ (Kir) channels allow K+ to move more easily into rather than out of the
cell. They have diverse physiological functions depending on their type and their location …

In responding to cytoplasmic nucleotide levels, ATP-sensitive potassium (KATP) channel
activity provides a unique link between cellular energetics and electrical excitability. Over …

ATP-sensitive potassium (KATP) channels are present in the surface and internal
membranes of cardiac, skeletal, and smooth muscle cells and provide a unique feedback …

Studies of ion channels have for long been dominated by the animalcentric, if not
anthropocentric, view of physiology. The structures and activities of ion channels had …

Over the past decade, there has been an explosion in the number of membrane transport
proteins that have been shown to be sensitive to the abundance of phosphoinositides in the …

Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the
progress made in this area of signaling research has yielded findings that offer the potential …

Crystallography has provided invaluable insights regarding ion-channel selectivity and
gating, but to advance understanding to a new level, dynamic views of channel structures …

General principles in biology have often been elucidated from the study of bacteria. This is
true for the bacterial mechanosensitive channel of large conductance, MscL, the channel …

KirBac channels are prokaryotic homologs of mammalian inwardly rectifying (Kir) potassium
channels, and recent crystal structures of both Kir and KirBac channels have provided major …

PKD2 and PKD1 genes are mutated in human autosomal dominant polycystic kidney
disease. PKD2 can form either a homomeric cation channel or a heteromeric complex with …