High blood pressure is present in more than one billion adults worldwide and is the most
important modifiable risk factor of death resulting from cardiovascular disease. While many …

Chronic and acute renal diseases, irrespective of the initiating cause, have inflammation and
immune system activation as a common underlying mechanism. The purpose of this review …

Systemic lupus erythematosus (SLE) is an autoimmune disease mediated by pathogenic
autoantibodies directed against nucleoprotein complexes. Beyond the activation of …

The resolution of inflammation is an active and dynamic process, mediated in large part by
the innate immune system. Resolution represents not only an increase in anti‐inflammatory …

The metabolic syndrome (MetS) is characterized by obesity concomitant with other
metabolic abnormalities such as hypertriglyceridemia, reduced high-density lipoprotein …

Lupus nephritis (LN) is a serious complication of systemic lupus erythematosus (SLE) that
occurs in about half of patients. LN is characterized by glomerular deposition of immune …

Autoimmune glomerulonephritis is a common manifestation of systemic lupus
erythematosus (SLE). In this study, we show that mice lacking macrophage expression of the …

Nuclear receptors are ligand-activated transcription factors linking lipid signaling to the
expression of the genome. There is increasing appreciation of the involvement of this …

Chronic inflammation has been implicated in the pathology of hypertension; however, the
role for specific cytokines remains unclear. We tested whether tumor necrosis factor-α …

Nuclear receptors represent a large family of ligand-activated transcription factors which
sense the physiological environment and make long-term adaptations by mediating …