Motivation Identification of blood–brain barrier (BBB) permeability of a compound is a major
challenge in neurotherapeutic drug discovery. Conventional approaches for BBB …

Traumatic brain injury, often referred to as the “silent epidemic,” is a nondegenerative, non-
congenital insult to the brain due to a blow or penetrating object that disrupts the function of …

Background Proteins from the ABC family (ATP-binding cassette) represent the largest
known group of efflux pumps, responsible for transporting specific molecules across lipid …

The blood‐brain barrier (BBB) is a highly controlled microenvironment that regulates the
interactions between cerebral blood and brain tissue. Due to its selectivity, many …

Traditional experimental approaches to evaluate the Blood-Brain Barrier (BBB) permeability
of a drug are expensive and time consuming. Hence, several computational models have …

The digestive tract constitutes an important interface between an animal's internal and
external environment. In insects, available gut transcriptome studies are mostly exploratory …

Annual losses of honey bee colonies remain high and pesticide exposure is one possible
cause. Dangerous combinations of pesticides, plant-produced compounds and antibiotics …

The metabolism of drugs in the brain is difficult to study in most species because of
enzymatic instability in vitro and interference from peripheral metabolism in vivo. A locust ex …

Studying how and where drugs are metabolized in the brain is challenging. In an entire
organism, peripheral metabolism produces many of the same metabolites as those in the …

The metabolism of midazolam was investigated in vivo in locusts in order to evaluate the
presence of an enzyme with functionality similar to human CYP3A4/5. 2. Hydroxylated …