Glucolipid metabolism disorder (GLMD) is a complex chronic disease characterized by
glucose and lipid metabolism disorders with a complex and diverse etiology and rapidly …

Metabolic disorders, encompassing diabetes mellitus, cardiovascular diseases,
gastrointestinal disorders, etc., pose a substantial global health threat, with rising morbidity …

Honokiol is a phytochemical component with a variety of pharmacological properties.
However, the major limitation of Honokiol is its poor solubility and low oral bioavailability. In …

This study aimed to investigate the anti-neuropathic pain activity and its underlying
molecular mechanism of Ajugarin-I (Aju-I) in a rat model of diabetic neuropathic pain. The …

Background A decrease in nitric oxide (NO) bioavailability has been shown to cause
hyperglycemia, type II diabetes mellitus (DM), and chronic cardio-metabolic complications …

Diabetic peripheral neuropathy (DPN) is a common diabetic complication. Chrysin (CHY)
has many biological properties but poor oral bioavailability. This study investigates the effect …

Introduction: Cardiac fibrosis is strongly induced by diabetic conditions. Both chrysin (CHR)
and calixarene OTX008, a specific inhibitor of galectin 1 (Gal-1), seem able to reduce …

Background Zinc oxide nanoparticles are nanoparticles of metal oxide with semiconductor
properties and proved many noxious effects on the mammalian cell. Sildenafil, a …

Diabetic kidney disease, known as diabetic nephropathy (DN), is a widespread severe
diabetes complication leading to kidney failure. Due to the lack of efficacious therapies, this …

Diabetes mellitus is a global health issue characterized by hyperglycemia which leads over
time to severe damage to numerous tissues. The present study aimed to estimate the effect …