Unlike other members of the TNF superfamily, the TNF-related apoptosis-inducing ligand
(TRAIL, also known as Apo2L) possesses the unique capacity to induce apoptosis …

Apoptosis or programmed cell death is a key regulator of physiological growth control and
regulation of tissue homeostasis. One of the most important advances in cancer research in …

Senescent cells play important roles in both physiological and pathological processes,
including cancer and aging. In all cases, however, senescent cells comprise only a small …

One of the hallmarks of human cancers is the intrinsic or acquired resistance to apoptosis.
Evasion of apoptosis may contribute to carcinogenesis, tumor progression and also to …

Simple Summary Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)
plays an important role in apoptosis and tumor immunosurveillance. Because TRAIL …

Programmed cell death via apoptosis is characteristically disturbed in human cancers. This
facilitates not only tumor formation and progression, but also treatment resistance. Since …

The p53 tumor suppressor limits cellular proliferation by inducing cell cycle arrest and
apoptosis in response to cellular stresses such as DNA damage, hypoxia, and oncogene …

Evasion of cell death is one of the hallmarks of cancer cells, beginning with long‐
established apoptosis and extending to other new forms of cell death. An elaboration of cell …

One of the hallmarks of human cancers is the intrinsic or acquired resistance to apoptosis.
Evasion of apoptosis can be part of a cellular stress response to ensure the cell′ s survival …

P53 is known as the most critical tumor suppressor and is often referred to as the guardian of
our genome. More than 40 years after its discovery, we are still struggling to understand all …