Iron is the most abundant transition metal within the brain, and is vital for a number of
cellular processes including neurotransmitter synthesis, myelination of neurons, and …

Copper is a trace element, important for the function of many cellular enzymes. Copper ions
can adopt distinct redox states oxidized Cu (II) or reduced (I), allowing the metal to play a …

Copper (Cu) is an essential micronutrient required for the activity of redox‐active enzymes
involved in critical metabolic reactions, signaling pathways, and biological functions …

Age related macular degeneration (AMD) is the leading cause of vision loss of those over
the age of 65 in the industrialized world. The prevalence and need to develop effective …

▪ Abstract Ceruloplasmin is a serum ferroxidase that contains greater than 95% of the copper
found in plasma. This protein is a member of the multicopper oxidase family, an …

Iron is an essential element for the development and functionality of the brain, and
anomalies in its distribution and concentration in brain tissue have been found to be …

Copper is an essential trace metal which plays a fundamental role in the biochemistry of the
human nervous system. Menkes disease and Wilson disease are inherited disorders of …

The cellular uptake and intracellular distribution of the essential but highly toxic nutrient,
copper, is a precisely orchestrated process. Copper homeostasis is coordinated by several …

Copper and iron are transition elements essential for life. These metals are required to
maintain the brain's biochemistry such that deficiency or excess of either copper or iron …

Iron must cross biological membranes to reach essential intracellular enzymes. Two proteins
in the plasma membrane of yeast—a multicopper oxidase, encoded by the FET3 gene, and …