Myriad genetic and epigenetic alterations are required to drive normal cells toward
malignant transformation. These somatic events commandeer many signaling pathways that …

Mammalian telomeres are formed by tandem repeats of the TTAGGG sequence, which are
progressively lost with each round of cell division. Telomere protection requires a minimal …

Stem cells are controlled, in part, by genetic pathways frequently dysregulated during
human tumorigenesis. Either stimulation of Wnt/β-catenin signalling or overexpression of …

Progressive DNA damage and mitochondrial decline are both considered to be prime
instigators of natural ageing. Traditionally, these two pathways have been viewed largely in …

Constitutive expression of telomerase in human cells prevents the onset of senescence and
crisis by maintaining telomere homeostasis. However, accumulating evidence suggests that …

The accumulated evidence has pointed to a key role of telomerase in carcinogenesis. As a
RNA-dependent DNA polymerase, telomerase synthesizes telomeric DNA at the end of …

Adult stem/progenitor are a small population of cells that reside in tissue-specific niches and
possess the potential to differentiate in all cell types of the organ in which they operate. Adult …

Telomerase has fundamental roles in bypassing cellular aging and in cancer progression by
maintaining telomere homeostasis and integrity. However, recent studies have led some …

The telomerase reverse transcriptase protein TERT has recently been demonstrated to have
a variety of functions both in vitro and in vivo, which are distinct from its canonical role in …

Human telomerase reverse transcriptase (hTERT) is localized to mitochondria, as well as
the nucleus, but details about its biology and function in the organelle remain largely …