From Animal Models to Clinical Trials: The Potential of Antimicrobials in Multiple Sclerosis Treatment

MF Raghib, E Bernitsas - Biomedicines, 2023 - mdpi.com
Multiple sclerosis (MS) is a chronic, autoimmune, demyelinating disease of the central
nervous system (CNS). Microbes, including bacteria and certain viruses, particularly Epstein …

The influence of aging and the microbiome in multiple sclerosis and other neurologic diseases

NM Fettig, A Pu, LC Osborne… - Immunological …, 2024 - Wiley Online Library
The human gut microbiome is well‐recognized as a key player in maintaining health.
However, it is a dynamic entity that changes across the lifespan. How the microbial changes …

Association of higher mediterranean diet adherence with lower prevalence of disability and symptom severity, depression, anxiety, stress, sleep quality, cognitive …

C Tryfonos, E Pavlidou, T Vorvolakos… - Journal of Geriatric …, 2024 - journals.sagepub.com
A good nutritional status and healthy diets may decelerate disease disability and symptom
severity and quality of life of peoples with multiple sclerosis (MS). Mediterranean diet (MD) …

Current and future role of MRI in the diagnosis and prognosis of multiple sclerosis

MA Rocca, P Preziosa, F Barkhof… - The Lancet Regional …, 2024 - thelancet.com
In the majority of cases, multiple sclerosis (MS) is characterized by reversible episodes of
neurological dysfunction, often followed by irreversible clinical disability. Accurate diagnostic …

Menopausal transition in multiple sclerosis: relationship with disease activity and brain volume measurements

L Lorefice, G Fenu, M Fronza, F Murgia, J Frau… - Frontiers in …, 2023 - frontiersin.org
Background Recent evidence has shown a significant association between menopause and
multiple sclerosis (MS) progression. This study investigated the possible role of menopause …

Biological variation estimates for serum neurofilament light chain in healthy subjects

A Carobene, K Maiese, C Abou-Diwan, M Locatelli… - Clinica Chimica …, 2023 - Elsevier
Abstract Objectives Neurofilament light chain (NfL) is an emerging biomarker of
neurodegeneration disorders. Knowledge of the biological variation (BV) can facilitate …

Treatment of older patients with multiple sclerosis: Results of an International Delphi Survey

H Tumani, PK Coyle, C Cárcamo… - Multiple Sclerosis …, 2023 - journals.sagepub.com
Background People over age 50–55 have historically been excluded from randomized
clinical trials for multiple sclerosis (MS). However, more than half of those living with an MS …

Aging-dependent change in Th17 and cytokine response in multiple sclerosis

W Zhu, S Revu, C Chen, M Dahl, A Ramkumar, C Kelly… - medRxiv, 2024 - medrxiv.org
Background: Multiple sclerosis (MS) is a chronic autoimmune disease damaging the central
nervous system. Diminished inflammatory disease activities (DAs) as people with MS …

Ocrelizumab associates with reduced cerebrospinal fluid B and CD20dim CD4+ T cells in primary progressive multiple sclerosis

F van Puijfelik, KM Blok… - Brain …, 2024 - academic.oup.com
The anti-CD20 monoclonal antibody ocrelizumab reduces disability progression in primary
progressive multiple sclerosis. CD20 is a prototypical B-cell marker; however …

Advanced MRI Techniques: Diagnosis and Follow-Up of Multiple Sclerosis

R Nistri, A Ianniello, V Pozzilli, C Giannì, C Pozzilli - Diagnostics, 2024 - mdpi.com
Brain and spinal cord imaging plays a pivotal role in aiding clinicians with the diagnosis and
monitoring of multiple sclerosis. Nevertheless, the significance of magnetic resonance …