Abstract The Trithorax group (TrxG) of proteins is a large family of epigenetic regulators that
form multiprotein complexes to counteract repressive developmental gene expression …

New methods for the genome-wide analysis of chromatin are providing insight into its roles
in development and their underlying mechanisms. Current studies indicate that chromatin is …

Mammalian SWI/SNF chromatin remodelling complexes exist in three distinct, final-form
assemblies: canonical BAF (cBAF), PBAF and a newly characterized non-canonical complex …

Cancer cells frequently depend on chromatin regulatory activities to maintain a malignant
phenotype. Here, we show that leukemia cells require the mammalian SWI/SNF chromatin …

Improved knowledge of all aspects of adipose biology will be required to counter the
burgeoning epidemic of obesity. Interest in adipogenesis has increased markedly over the …

A detailed understanding of the processes governing adipose tissue formation will be
instrumental in combating the obesity epidemic. Much progress has been made in the last …

Enhancer activity drives cell differentiation and cell fate determination, but it remains unclear
how enhancers cooperate during these processes. Here we investigate enhancer …

Precise gene expression ensures proper stem and progenitor cell differentiation, lineage
commitment and organogenesis during mammalian development. ATP-dependent …

The SWI/SNF complexes, initially identified in yeast 20 years ago, are a family of multi-
subunit complexes that use the energy of adenosine triphosphate (ATP) hydrolysis to …

The CEBPA gene is mutated in 9% of patients with acute myeloid leukemia (AML). Selective
expression of a short (30-kDa) CCAAT-enhancer binding protein-α (C/EBPα) translational …