Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

NMDA-type glutamate receptors are ligand-gated ion channels that mediate a Ca2+-
permeable component of excitatory neurotransmission in the central nervous system (CNS) …

Abstract N-methyl-d-aspartate (NMDA) receptors are Hebbian-like coincidence detectors,
requiring binding of glycine and glutamate in combination with the relief of voltage …

Structure, Function, and Pharmacology of NMDA Receptor Channels Page 1
PHYSIOLOGICAL RESEARCH • ISSN 0862-8408(print) • ISSN 1802-9973(online) © 2014 …

N-methyl-d-aspartate receptors (NMDARs) are present at many excitatory glutamate
synapses in the central nervous system and display unique properties that depend on their …

ACTIVATION of the N-methyl-d-aspartate (NMDA) receptor is important for certain forms of
activity-dependent synaptic plasticity, such as long-term potentiation (reviewed in ref. 1), and …

Alzheimer's disease (AD) is the most common form of dementia, accounting for 60–70% of
cases in subjects over 65 years of age. Several postulates have been put forward that relate …

The N-methyl-D-aspartate (NMDA) receptor subserves synaptic glutamate-induced
transmission and plasticity in central neurons. The yeast two-hybrid system was used to …

The glutamate receptors mediate excitatory neurotransmission in the brain and are
important in memory acquisition, learning, and some neurodegenerative disorders. This …

Glutamate receptors (GluRs) mediate most of the excitatory neurotransmission in the
mammalian central nervous system (CNS). In addition, they are involved in plastic changes …