PF-543 is a sphingosine kinase 1 (SPHK1) inhibitor developed by Pfizer and is currently
considered the most potent selective SPHK1 inhibitor. SPHK1 catalyses the production of …

Premature infants are born with developing lungs burdened by surfactant deficiency and a
dearth of antioxidant defense systems. Survival rate of such infants has significantly …

Bronchopulmonary dysplasia (BPD) is a common chronic lung disease in premature infants.
Accumulating evidence shows that dysregulated metabolism of glucose, lipids and amino …

Sphingosine kinase 1 (SPHK1) has been shown to play a key role in the pathogenesis of
asthma where SPHK1-generated sphingosine-1-phosphate (S1P) is known to mediate …

Acute lung injury (ALI) is a frequent complication of sepsis, with pyroptosis playing a pivotal
role. Analysis of Gene Expression Omnibus (GEO) mouse sepsis datasets revealed the …

Background & Aims Epithelial disruption in eosinophilic esophagitis (EoE) encompasses
both impaired differentiation and diminished barrier integrity. We have shown that lysyl …

Purpose To detect the expression of sphingosine kinase 1 (SPHK1) in clear cell renal cell
carcinoma (ccRCC) and explore its biological role in the occurrence and development of …

Objective To compare conventional gas ventilation (GV) and high-frequency oscillatory
ventilation (HFOV) for weaning from total liquid ventilation (TLV). Methods Sixteen lambs …

1-磷酸鞘氨醇(S1P) 是磷脂代谢过程中的主要产物, 具有促进细胞增殖, 迁移, 凋亡,
维持血管内皮屏障功能等作用. 最新研究显示, S1P 能够减轻急性肺损伤(ALI) …

Abstract An overview of Prof. Viswanathan Natarajan's journey in academia as a mentor,
teacher, and lipid scientist for nearly 50 years is presented. As a graduate student, Dr …