PGC-1α-mediated regulation of mitochondrial function and physiological implications
JF Halling, H Pilegaard - Applied Physiology, Nutrition, and …, 2020 - cdnsciencepub.com
The majority of human energy metabolism occurs in skeletal muscle mitochondria
emphasizing the importance of understanding the regulation of myocellular mitochondrial …
emphasizing the importance of understanding the regulation of myocellular mitochondrial …
Hepatic transcriptional responses to fasting and feeding
L Bideyan, R Nagari, P Tontonoz - Genes & development, 2021 - genesdev.cshlp.org
Mammals undergo regular cycles of fasting and feeding that engage dynamic transcriptional
responses in metabolic tissues. Here we review advances in our understanding of the gene …
responses in metabolic tissues. Here we review advances in our understanding of the gene …
[HTML][HTML] Anti-diabetic effect by walnut (Juglans mandshurica Maxim.)-derived peptide LPLLR through inhibiting α-glucosidase and α-amylase, and alleviating insulin …
J Wang, T Wu, L Fang, C Liu, X Liu, H Li, J Shi… - Journal of Functional …, 2020 - Elsevier
In the present study, a novel pentapeptide LPLLR (Leu-Pro-Leu-Leu-Arg) was purified and
identified from walnut protein hydrolysates (3–10 kDa) by SEC, RP-HPLC, and LC-MS/MS …
identified from walnut protein hydrolysates (3–10 kDa) by SEC, RP-HPLC, and LC-MS/MS …
The role of mitochondria in the pathogenesis of type 2 diabetes
The pathophysiology of type 2 diabetes mellitus (DM) is varied and complex. However, the
association of DM with obesity and inactivity indicates an important, and potentially …
association of DM with obesity and inactivity indicates an important, and potentially …
PGC-1α regulation by exercise training and its influences on muscle function and insulin sensitivity
The peroxisome proliferator-activated receptor-γ (PPARγ) coactivator-1α (PGC-1α) is a
major regulator of exercise-induced phenotypic adaptation and substrate utilization. We …
major regulator of exercise-induced phenotypic adaptation and substrate utilization. We …
PGC-1 coactivators in cardiac development and disease
The beating heart requires a constant flux of ATP to maintain contractile function, and there
is increasing evidence that energetic defects contribute to the development of heart failure …
is increasing evidence that energetic defects contribute to the development of heart failure …
The role of adipose tissue and lipotoxicity in the pathogenesis of type 2 diabetes
K Cusi - Current diabetes reports, 2010 - Springer
The widespread epidemics of obesity and type 2 diabetes mellitus (T2DM) suggest that both
conditions are closely linked. An increasing body of evidence has shifted our view of …
conditions are closely linked. An increasing body of evidence has shifted our view of …
Mesenchymal stem cell treatment for peripheral nerve injury: a narrative review
RC Zhang, WQ Du, JY Zhang, SX Yu… - Neural regeneration …, 2021 - journals.lww.com
Peripheral nerve injuries occur as the result of sudden trauma and lead to reduced quality of
life. The peripheral nervous system has an inherent capability to regenerate axons …
life. The peripheral nervous system has an inherent capability to regenerate axons …
[HTML][HTML] Alzheimer's disease: the amyloid hypothesis and the Inverse Warburg effect
LA Demetrius, PJ Magistretti, L Pellerin - Frontiers in physiology, 2015 - frontiersin.org
Epidemiological and biochemical studies show that the sporadic forms of Alzheimer's
disease (AD) are characterized by the following hallmarks:(a) An exponential increase with …
disease (AD) are characterized by the following hallmarks:(a) An exponential increase with …
Dissociating fatty liver and diabetes
Z Sun, MA Lazar - Trends in endocrinology & metabolism, 2013 - cell.com
Fatty liver disease is epidemiologically associated with type 2 diabetes (T2D), leading to a
speculation of a reciprocal cause–effect relationship and a vicious cycle of pathology. Here …
speculation of a reciprocal cause–effect relationship and a vicious cycle of pathology. Here …