Primary immunodeficiencies (PID) are disorders that for the most part result from mutations
in genes involved in immune host defense and immunoregulation. These conditions are …

Fifty years have elapsed since the term common variable immunodeficiency (CVID) was
introduced to accommodate the many and varied antibody deficiencies being identified in …

Severe combined immunodeficiencies (SCIDs) comprise a group of rare, monogenic
diseases that are characterized by an early onset and a profound block in the development …

Can genetic and clinical findings made in a single patient be considered sufficient to
establish a causal relationship between genotype and phenotype? We report that up to 49 of …

The use of chimeric antigen receptor (CAR)-engineered regulatory T cells (Tregs) has
emerged as a promising strategy to promote immune tolerance. However, in conventional T …

In addition to susceptibility to infections, conventional primary immunodeficiency disorders
(PIDs) and inborn errors of immunity (IEI) can cause immune dysregulation, manifesting as …

Primary antibody deficiencies (PADs) are the most common inherited immunodeficiencies in
humans. The use of novel approaches, such as whole-exome sequencing and mouse …

Severe combined immunodeficiency (SCID) results from defects in the differentiation of
hematopoietic stem cells into mature T lymphocytes, with additional lymphoid lineages …

In the past, primary immunodeficiency disorders (PIDs) have been described as diseases
caused by 1 or more defects of the immune system, leading to increased susceptibility to …

Autoimmunity and immune dysregulation may lead to cytopenia and represent key features
of many primary immunodeficiencies (PIDs). Especially when cytopenia is the initial …