Gut microbiota and immune system interactions
Dynamic interactions between gut microbiota and a host's innate and adaptive immune
systems are essential in maintaining intestinal homeostasis and inhibiting inflammation. Gut …
systems are essential in maintaining intestinal homeostasis and inhibiting inflammation. Gut …
[HTML][HTML] Mouse microbiota models: comparing germ-free mice and antibiotics treatment as tools for modifying gut bacteria
As the intestinal microbiota has become better appreciated as necessary for maintenance of
physiologic homeostasis and also as a modulator of disease processes, there has been a …
physiologic homeostasis and also as a modulator of disease processes, there has been a …
[HTML][HTML] The maternal microbiome modulates fetal neurodevelopment in mice
Abstract 'Dysbiosis' of the maternal gut microbiome, in response to challenges such as
infection, altered diet and stress during pregnancy, has been increasingly associated with …
infection, altered diet and stress during pregnancy, has been increasingly associated with …
[HTML][HTML] The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL
Bacterial dysbiosis accompanies carcinogenesis in malignancies such as colon and liver
cancer, and has recently been implicated in the pathogenesis of pancreatic ductal …
cancer, and has recently been implicated in the pathogenesis of pancreatic ductal …
[HTML][HTML] Local immune response to food antigens drives meal-induced abdominal pain
J Aguilera-Lizarraga, MV Florens, MF Viola, P Jain… - Nature, 2021 - nature.com
Up to 20% of people worldwide develop gastrointestinal symptoms following a meal, leading
to decreased quality of life, substantial morbidity and high medical costs. Although the …
to decreased quality of life, substantial morbidity and high medical costs. Although the …
[HTML][HTML] Caspase-7 activates ASM to repair gasdermin and perforin pores
Among the caspases that cause regulated cell death, a unique function for caspase-7 has
remained elusive. Caspase-3 performs apoptosis, whereas caspase-7 is typically …
remained elusive. Caspase-3 performs apoptosis, whereas caspase-7 is typically …
The pancreatic cancer microbiome promotes oncogenesis by induction of innate and adaptive immune suppression
We found that the cancerous pancreas harbors a markedly more abundant microbiome
compared with normal pancreas in both mice and humans, and select bacteria are …
compared with normal pancreas in both mice and humans, and select bacteria are …
The gut microbiota mediates the anti-seizure effects of the ketogenic diet
The ketogenic diet (KD) is used to treat refractory epilepsy, but the mechanisms underlying
its neuroprotective effects remain unclear. Here, we show that the gut microbiota is altered …
its neuroprotective effects remain unclear. Here, we show that the gut microbiota is altered …
Western diet contributes to the pathogenesis of non-alcoholic steatohepatitis in male mice via remodeling gut microbiota and increasing production of 2-oleoylglycerol
The interplay between western diet and gut microbiota drives the development of non-
alcoholic fatty liver disease and its progression to non-alcoholic steatohepatitis. However …
alcoholic fatty liver disease and its progression to non-alcoholic steatohepatitis. However …
Intestinal microbiota shapes gut physiology and regulates enteric neurons and glia
FA Vicentini, CM Keenan, LE Wallace, C Woods… - Microbiome, 2021 - Springer
Background The intestinal microbiota plays an important role in regulating gastrointestinal
(GI) physiology in part through interactions with the enteric nervous system (ENS) …
(GI) physiology in part through interactions with the enteric nervous system (ENS) …