Recent years have witnessed rapid advances in molecular cytogenetics and its impact in
studying mental retardation (MR). We review new molecular cytogenetic methods, including …

A technique used to amplify the number of copies of a specific region of DNA, the
polymerase chain reaction (PCR) is at the forefront of the dramatic development of …

The advent of molecular genetic techniques has brought forth new procedures for in situ
chromosomal analysis. One of these techniques is the primed in situ labeling (PRINS) …

A technique used to amplify the number of copies of a specific region of DNA, the
polymerase chain reaction (PCR) is at the forefront of the dramatic development of …

Low copy repeats (LCRs) located in 22q11. 2, especially LCR-B, are susceptible to
rearrangements associated with several relatively common constitutional disorders. These …

Decades before the recent advances in molecular biology and the knowledge of the
complete nucleotide sequence of several genomes, cytogenetic analysis provided the first …

Rearrangements involving the 13q14 and 17p13 chromosomal regions are often observed
in leukemias and lymphomas. These rearrangements are not always identifiable …

The aim of this study is to validate the multi‐PRINS (primed in situ labelling) technique for
simultaneous detection of chromosomes 18, X and Y in uncultured amniocytes for prenatal …

Abstract Both PRimed IN Situ (PRINS) and Peptide Nucleic Acid (PNA) technologies have
emerged as research techniques, but they have quickly evolved to applications in biological …

Cytogenetics conventionally means study of chromosomes by microscopy. However, in
broader sense, it is a branch of genetics devoted to cellular constituents concerned in …