Aberrant expression and activity of G proteins and G-protein-coupled receptors (GPCRs) are
frequently associated with tumorigenesis. Deep sequencing studies show that 4.2% of …

G-protein-coupled receptors (GPCRs), the largest family of cell-surface molecules involved
in signal transmission, have recently emerged as crucial players in tumour growth and …

β-arrestins are versatile adapter proteins that form complexes with most G-protein-coupled
receptors (GPCRs) following agonist binding and phosphorylation of receptors by G-protein …

Using both confocal immunofluorescence microscopy and biochemical approaches, we
have examined the role of β-arrestins in the activation and targeting of extracellular signal …

G proteins provide signal-coupling mechanisms to heptahelical cell surface receptors and
are critically involved in the regulation of different mitogen-activated protein kinase (MAPK) …

In Drosophila, members of the frizzled family of tissue-polarity genes encode proteins that
are likely to function as cell-surface receptors of the type known as Wnt receptors, and to …

Receptors coupled to heterotrimeric GTP-binding proteins (G proteins) are integral
membrane proteins involved in the transmission of signals from the extracellular …

Mitogenic signaling by G-protein-coupled receptors (GPCRs) involves tyrosine
phosphorylation of adaptor proteins and assembly of multiprotein Ras activation complexes …

Adrenal tumors autonomously producing cortisol cause Cushing's syndrome,,,. We
performed exome sequencing of 25 tumor-normal pairs and identified 2 subgroups. Eight …

FSH stimulates in ovarian granulosa cells diverse, differentiation-dependent responses that
implicate activation of specific cellular signaling cascades. In these studies three kinases …