Chronic pain conditions are multifactorial disorders with a high frequency in the population.
Their pathophysiology is often unclear, and treatment is inefficient. During the last 20 years …

Migraine is a common neurological disorder and can be severely disabling during attacks.
The highest prevalence occurs between the ages of 25 and 55 years, potentially the most …

ContextMigraine with aura has been associated with an adverse cardiovascular risk profile
and prothrombotic factors that, along with migraine-specific physiology, may increase the …

Insight into the molecular mechanisms involved in primary headaches is important to identify
drug targets for improving treatment of patients, but essentially lacking. Genetic research is …

Epidemiological studies suggests that migraine is associated with disorders of the cerebral,
coronary, retinal, dermal and peripheral vasculature. There is evidence that migraine is …

Objective/Background Migraine is associated with ischemic stroke. Women are 3‐fold as
likely as men to have migraine, and high estrogen states increase the risk of migraine with …

(Headache 2010; 50: 588‐599) Background.—Data on the association between the MTHFR
677C> T and ACE D/I polymorphisms and migraine including aura status are conflicting …

Polygenic profiling has been proposed for elite endurance performance, using an additive
model determining the proportion of optimal alleles in endurance athletes. To investigate …

Migraine has been associated with an unfavourable cardiovascular risk profile and with
increased risk of cardiovascular disease. In a cross-sectional analysis of 17 616 women …

The migraine-ischemia relationship is best understood in the context of the pathophysiology
of migraine. Potential mechanisms of migrainous infarction (stroke occurring during …