Poly (ADP-ribosyl) ation is an immediate cellular repair response to DNA damage and is
catalyzed primarily by poly (ADP-ribose) polymerase-1 (PARP1), which is the most …

Accumulating evidence suggests that the reactive oxygen and nitrogen species are
generated in cardiomyocytes and endothelial cells during myocardial ischemia/reperfusion …

PIWI-interacting RNAs (piRNAs) are abundantly expressed during cardiac hypertrophy.
However, their functions and molecular mechanisms remain unknown. Here, we identified a …

Global epidemiological studies reported a shift from maternal/infectious communicable
diseases to chronic non-communicable diseases and a major part is attributable to …

Magnesium is a vital cation that takes part in many cellular processes. Magnesium balance
can be disturbed in multiple conditions, and differences in magnesium concentration can be …

Despite great advances in therapies observed during the last decades, heart failure (HF)
remained a major health problem in western countries. In order to further improve symptoms …

Chromatin regulation provides an important means for controlling cardiac gene expression
under different physiological and pathological conditions. Processes that direct the …

Poly (ADP-ribose) polymerase (PARP) inhibitors have recently been introduced in the
therapy of several types of cancers not responding to conventional treatments. However, de …

Pathological stress from cardiovascular disease stimulates hypertrophy of heart cells, which
increases the risk of cardiac morbidity and mortality. Recent evidence has indicated that …

The type and quantity of dietary fat ingested contributes to the onset and progression of
chronic diseases, like diabetes and atherosclerosis. The liver plays a central role in whole …