The OFD1 protein is necessary for the formation of primary cilia and left–right asymmetry
establishment but additional functions have also been ascribed to this multitask protein …

Primary cilia are microtubule-based, non-motile sensory organelles present in most types of
growth-arrested eukaryotic cells. They are transduction hubs that receive and transmit …

Osteoarthritis (OA) is a complex condition that involves both apoptosis and senescence and
currently cannot be cured. Fibroblast growth factor 21 (FGF21), known for its role as a potent …

Autophagy regulates primary cilia formation, but the underlying mechanism is not fully
understood. In this study, we identify NIMA-related kinase 9 (NEK9) as a GABARAPs …

Tumor Treating Fields (TTFields) are low-intensity, alternating intermediate-frequency (200
kHz) electrical fields that extend survival of glioblastoma patients receiving maintenance …

Highlights•Targeting autophagy has become a hot tumor-therapeutic strategy.•The drug
repurposing strategy is emerging as a good option to discover new treatments.•Many FDA …

Macroautophagy/autophagy is a self-degradative process necessary for cells to maintain
their energy balance during development and in response to nutrient deprivation …

Cilia are microtubule-based organelles that project from the cell surface with motility or
sensory functions. Primary cilia work as antennae to sense and transduce extracellular …

Melanoma is a deadly form of cancer characterized by remarkable therapy resistance.
Analyzing the transcriptome of MAPK inhibitor sensitive-and resistant-melanoma, we …

The balance of protein synthesis and degradation is finely regulated and influences cellular
homeostasis and biological processes (eg, embryonic development and neuronal plasticity) …