Blood and immune cells derive from multipotent hematopoietic stem cells (HSCs).
Classically, stem and progenitor populations have been considered discrete homogeneous …

Stem cells are considered the fundamental underpinnings of tissue biology. The stem cell
microenvironment provides factors and elements that play significant roles in controlling the …

Hematopoietic stem cells (HSCs) are fundamental to the generation of the body's blood and
immune cells. They reside primarily within the bone marrow (BM) niche microenvironment …

Here, we propose a collagen-based three-dimensional (3D) environment for hematopoietic
stem and progenitor cells (HPC) with mesenchymal stem cells (MSC) derived either from …

Megakaryocytes associate with the bone marrow vasculature where they convert their
cytoplasm into proplatelets that protrude through the vascular endothelium into the lumen …

Umbilical cord blood (CB) is a rich source of hematopoietic stem cells (HSCs) with important
applications in allogeneic stem cell transplantation. However, the low numbers of …

Hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) play key roles
in the production of mature blood cells and in the biology and clinical outcomes of …

Hematopoietic stem cells (HSCs) are adult multipotential stem cells with the capacity to
differentiate into all blood cells and immune cells, which are essential for maintaining …

Hematopoietic stem cells (HSCs) have proven their clinical relevance in stem cell
transplantation to cure patients with hematological disorders. Key to their regenerative …

The ability of stem cells to self‐renew with minimal or no differentiation and, when
appropriately cued, to give rise to many types of progenitor and mature cells, is the basis for …