Intervertebral disc human nucleus pulposus cells associated with back pain trigger neurite outgrowth in vitro and pain behaviors in rats
W Jiang, JD Glaeser, G Kaneda, J Sheyn… - Science Translational …, 2023 - science.org
Low back pain (LBP) is often associated with the degeneration of human intervertebral discs
(IVDs). However, the pain-inducing mechanism in degenerating discs remains to be …
(IVDs). However, the pain-inducing mechanism in degenerating discs remains to be …
Preventive Roles of Rice-koji Extracts and Ergothioneine on Anxiety- and Pain-like Responses under Psychophysical Stress Conditions in Male Mice
K Piriyaprasath, Y Kakihara, A Kurahashi, M Taiyoji… - Nutrients, 2023 - mdpi.com
This study determined the effect of daily administration of Rice-koji on anxiety and
nociception in mice subjected to repeated forced swim stress (FST). In a parallel experiment …
nociception in mice subjected to repeated forced swim stress (FST). In a parallel experiment …
Regulation of pain neurotransmitters and chondrocytes metabolism mediated by voltage-gated ion channels: A narrative review
X Wang, X Li - Heliyon, 2023 - cell.com
Osteoarthritis (OA) is one of the leading causes of chronic pain and dysfunction. It is
essential to comprehend the nature of pain and cartilage degeneration and its influencing …
essential to comprehend the nature of pain and cartilage degeneration and its influencing …
Functional validation of co‐culture model of human keratinocytes and neuronal cell line for sensitive skin by using transient receptor potential channel vanilloid …
SM Shin, EJ Baek, DY Oh, KH Kim… - Skin Research and …, 2023 - Wiley Online Library
Background Sensitive skin is a subjective cutaneous hyper‐reactivity that occurs in
response to various innocuous stimuli. Keratinocytes have recently been shown to …
response to various innocuous stimuli. Keratinocytes have recently been shown to …
[HTML][HTML] Snake and arthropod venoms: Search for inflammatory activity in human cells involved in joint diseases
MP Alvarez-Flores, IFC Batista, IMV Boas, MC Bufalo… - Toxicon, 2024 - Elsevier
Most anti-inflammatory drugs currently adopted to treat chronic inflammatory joint diseases
can alleviate symptoms but they do not lead to remission. Therefore, new and more efficient …
can alleviate symptoms but they do not lead to remission. Therefore, new and more efficient …
Bilirubin oxidation end product B prevents CoCl2-induced primary cortical neuron apoptosis by promoting cell survival Akt/mTOR/p70S6K signaling pathway
J Liu, L Kong, D Chen, H Tang, Y Lu, Y Yuan… - Biochemical and …, 2022 - Elsevier
Bilirubin oxidation end products (BOXes) are associated with the late-developing
neurological deficits after subarachnoid hemorrhage (SAH) possibly by direct constricting …
neurological deficits after subarachnoid hemorrhage (SAH) possibly by direct constricting …
[HTML][HTML] 3D human stem-cell-derived neuronal spheroids for in vitro neurotoxicity testing of methylglyoxal, highly reactive glycolysis byproduct and potent glycating …
T Coccini, F Caloni, LA Russo, L Villani, D Lonati… - Current Research in …, 2024 - Elsevier
Abstract Human-derived three-dimensional (3D) in vitro models are advanced human cell-
based model for their complexity, relevance and application in toxicity testing. Intracellular …
based model for their complexity, relevance and application in toxicity testing. Intracellular …
[HTML][HTML] Mimicking the Human Articular Joint with In Vitro Model of Neurons-Synoviocytes Co-Culture
J Chwastek, M Kędziora, M Borczyk… - … Journal of Stem …, 2024 - synapse.koreamed.org
The development of in vitro models is essential in modern science due to the need for
experiments using human material and the reduction in the number of laboratory animals …
experiments using human material and the reduction in the number of laboratory animals …
Environmentally stressed human nucleus pulposus cells trigger the onset of discogenic low back pain
W Jiang, JD Glaeser, G Kaneda, J Sheyn, JT Wechsler… - bioRxiv, 2023 - biorxiv.org
Low back pain (LBP) is often associated with the degeneration of human intervertebral discs
(IVDs). However, the pain-inducing mechanism in degenerating discs remains to be …
(IVDs). However, the pain-inducing mechanism in degenerating discs remains to be …
Correction: Bufalo et al. Human Sensory Neuron-like Cells and Glycated Collagen Matrix as a Model for the Screening of Analgesic Compounds. Cells 2022, 11, 247
MC Bufalo, MES Almeida, JR Jensen… - Cells, 2024 - mdpi.com
Cells | Free Full-Text | Correction: Bufalo et al. Human Sensory Neuron-like Cells and Glycated
Collagen Matrix as a Model for the Screening of Analgesic Compounds. Cells 2022, 11, 247 Next …
Collagen Matrix as a Model for the Screening of Analgesic Compounds. Cells 2022, 11, 247 Next …