A global view of the genetic basis of Alzheimer disease
C Reitz, MA Pericak-Vance, T Foroud… - Nature Reviews …, 2023 - nature.com
The risk of Alzheimer disease (AD) increases with age, family history and informative genetic
variants. Sadly, there is still no cure or means of prevention. As in other complex diseases …
variants. Sadly, there is still no cure or means of prevention. As in other complex diseases …
Genetic variation, brain, and intelligence differences
Individual differences in human intelligence, as assessed using cognitive test scores, have a
well-replicated, hierarchical phenotypic covariance structure. They are substantially stable …
well-replicated, hierarchical phenotypic covariance structure. They are substantially stable …
An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank
UK Biobank is a major prospective epidemiological study, including multimodal brain
imaging, genetics and ongoing health outcomes. Previously, we published genome-wide …
imaging, genetics and ongoing health outcomes. Previously, we published genome-wide …
Heritability and interindividual variability of regional structure-function coupling
White matter structural connections are likely to support flow of functional activation or
functional connectivity. While the relationship between structural and functional connectivity …
functional connectivity. While the relationship between structural and functional connectivity …
Brain expression quantitative trait locus and network analyses reveal downstream effects and putative drivers for brain-related diseases
Identification of therapeutic targets from genome-wide association studies (GWAS) requires
insights into downstream functional consequences. We harmonized 8,613 RNA-sequencing …
insights into downstream functional consequences. We harmonized 8,613 RNA-sequencing …
Investigating the genetic architecture of noncognitive skills using GWAS-by-subtraction
Little is known about the genetic architecture of traits affecting educational attainment other
than cognitive ability. We used genomic structural equation modeling and prior genome …
than cognitive ability. We used genomic structural equation modeling and prior genome …
Evaluating the efficacy and mechanism of metformin targets on reducing Alzheimer's disease risk in the general population: a Mendelian randomisation study
Aims/hypothesis Metformin use has been associated with reduced incidence of dementia in
diabetic individuals in observational studies. However, the causality between the two in the …
diabetic individuals in observational studies. However, the causality between the two in the …
Common genetic variation influencing human white matter microstructure
INTRODUCTION White matter in the human brain serves a critical role in organizing
distributed neural networks. Diffusion magnetic resonance imaging (dMRI) has enabled the …
distributed neural networks. Diffusion magnetic resonance imaging (dMRI) has enabled the …
Genetic analyses identify brain structures related to cognitive impairment associated with elevated blood pressure
M Siedlinski, L Carnevale, X Xu… - European heart …, 2023 - academic.oup.com
Background and aims Observational studies have linked elevated blood pressure (BP) to
impaired cognitive function. However, the functional and structural changes in the brain that …
impaired cognitive function. However, the functional and structural changes in the brain that …
A general dimension of genetic sharing across diverse cognitive traits inferred from molecular data
It has been known since 1904 that, in humans, diverse cognitive traits are positively
intercorrelated. This forms the basis for the general factor of intelligence (g). Here, we …
intercorrelated. This forms the basis for the general factor of intelligence (g). Here, we …