Aging is the greatest risk factor for a multitude of diseases including cardiovascular disease,
neurodegeneration and cancer. Despite decades of research dedicated to understanding …

Superoxide dismutases (SODs) are universal enzymes of organisms that live in the
presence of oxygen. They catalyze the conversion of superoxide into oxygen and hydrogen …

While aging was traditionally viewed as a stochastic process of damage accumulation, it is
now clear that aging is strongly influenced by genetics. The identification and …

This chapter focuses on the introduction of molecular signaling pathways involved in
regulating the toxicity of environmental toxicants or stresses in Caenorhabditis elegans …

Mild deficits in mitochondrial function have been shown to increase lifespan in multiple
species including worms, flies and mice. Here, we study three C. elegans mitochondrial …

Caenorhabditis elegans has been used as a major model organism to identify genetic
factors that regulate organismal aging and longevity. Insulin/insulin-like growth factor 1 (IGF …

The reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) protects
against redox stress by providing reducing equivalents to antioxidants such as glutathione …

Background The mitochondrial unfolded protein response (mitoUPR) is a stress response
pathway activated by disruption of proteostasis in the mitochondria. This pathway has been …

Mitochondria perform a myriad of essential functions that ensure organismal homeostasis,
including maintaining bioenergetic capacity, sensing and signalling the presence of …

While the pathogenesis of Parkinson's disease (PD) is incompletely understood,
mitochondrial dysfunction is thought to play a crucial role in disease pathogenesis. Here, we …