Micronucleus assay: the state of art, and future directions

S Sommer, I Buraczewska, M Kruszewski - International journal of …, 2020 - mdpi.com
During almost 40 years of use, the micronucleus assay (MN) has become one of the most
popular methods to assess genotoxicity of different chemical and physical factors, including …

Putative origins of cell-free DNA in humans: a review of active and passive nucleic acid release mechanisms

S Grabuschnig, AJ Bronkhorst, S Holdenrieder… - International journal of …, 2020 - mdpi.com
Through various pathways of cell death, degradation, and regulated extrusion, partial or
complete genomes of various origins (eg, host cells, fetal cells, and infiltrating viruses and …

Catastrophic nuclear envelope collapse in cancer cell micronuclei

EM Hatch, AH Fischer, TJ Deerinck, MW Hetzer - Cell, 2013 - cell.com
During mitotic exit, missegregated chromosomes can recruit their own nuclear envelope
(NE) to form micronuclei (MN). MN have reduced functioning compared to primary nuclei in …

Micronuclei as biomarkers of DNA damage, aneuploidy, inducers of chromosomal hypermutation and as sources of pro-inflammatory DNA in humans

M Fenech, S Knasmueller, C Bolognesi… - … Research/Reviews in …, 2020 - Elsevier
Micronuclei (MNi) are among the most widely studied biomarkers of DNA damage and
chromosomal instability in humans. They originate from chromosome fragments or intact …

Resveratrol and neuroprotection: impact and its therapeutic potential in Alzheimer's disease

MH Rahman, R Akter, T Bhattacharya… - Frontiers in …, 2020 - frontiersin.org
Alzheimer's disease (AD) is a progressive cortex and hippocampal neurodegenerative
disease which ultimately causes cognitively impaired decline in patients. The AD pathogen …

Resveratrol and neuroprotection: an insight into prospective therapeutic approaches against Alzheimer's disease from bench to bedside

F Islam, MH Nafady, MR Islam, S Saha, S Rashid… - Molecular …, 2022 - Springer
Alzheimer's disease (AD) is the most common cause of dementia and cognitive impairment;
yet, there is currently no treatment. A buildup of Aβ, tau protein phosphorylation, oxidative …

Buccal micronucleus cytome assay

P Thomas, N Holland, C Bolognesi, M Kirsch-Volders… - Nature protocols, 2009 - nature.com
Abstract The Buccal Micronucleus Cytome (BMCyt) assay is a minimally invasive method for
studying DNA damage, chromosomal instability, cell death and the regenerative potential of …

The HUman MicroNucleus project on eXfoLiated buccal cells (HUMNXL): The role of life-style, host factors, occupational exposures, health status, and assay protocol

S Bonassi, E Coskun, M Ceppi, C Lando… - … Research/Reviews in …, 2011 - Elsevier
The human buccal micronucleus cytome assay (BMCyt) is one of the most widely used
techniques to measure genetic damage in human population studies. Reducing protocol …

[HTML][HTML] Protective effects of micronutrient supplements, phytochemicals and phytochemical-rich beverages and foods against DNA damage in humans: a systematic …

MF Fenech, CF Bull, BJW Van Klinken - Advances in Nutrition, 2023 - Elsevier
Accumulation of deoxyribonucleic acid (DNA) damage diminishes cellular health, increases
risk of developmental and degenerative diseases, and accelerates aging. Optimizing …

The HUMNxl scoring criteria for different cell types and nuclear anomalies in the buccal micronucleus cytome assay–An update and expanded photogallery

C Bolognesi, S Knasmueller, A Nersesyan… - … Research/Reviews in …, 2013 - Elsevier
The buccal micronucleus cytome assay is a minimally invasive cytological and interphase
cytogenetic technique for measuring DNA damage and cell death biomarkers in the oral …