In all living organisms, the phosphorylation of proteins modulates various aspects of their
functionalities. In eukaryotes, protein phosphorylation plays a key role in cell signaling, gene …

The diversity and dynamics of proteins play essential roles in maintaining the basic
constructions and functions of cells. The abundance of functional proteins is regulated by the …

The main family of serine/threonine/tyrosine protein kinases present in eukarya was defined
and described by Hanks et al. in 1988 (Science, 241, 42–52). It was initially believed that …

Reversible protein phosphorylation is the main mechanism of signal transduction that
enables cells to rapidly respond to environmental changes by controlling the functional …

The bacterial serine-threonine protein kinase HipA promotes multidrug tolerance by
phosphorylating the glutamate-tRNA ligase (GltX), leading to a halt in translation, inhibition …

Protein phosphorylation regulates a large variety of biological processes in all living cells. In
pathogenic bacteria, the study of serine, threonine, and tyrosine (Ser/Thr/Tyr) …

Pathogenic streptococcal species are responsible for a broad spectrum of human diseases
ranging from non-invasive and localized infections to more aggressive and life-threatening …

Soil-dwelling Streptomyces bacteria such as S. coelicolor have to constantly adapt to the
nitrogen (N) availability in their habitat. Thus, strict transcriptional and post-translational …

Streptococcus pneumoniae is an opportunistic human bacterial pathogen that usually
colonizes the upper respiratory tract, but the invasion and survival mechanism in respiratory …

Understanding phosphorylation-mediated regulation of metabolic enzymes, pathways, and
cell phenotypes under metabolic shifts represents a major challenge. The kinases …