Spinal cord injury: molecular mechanisms and therapeutic interventions

X Hu, W Xu, Y Ren, Z Wang, X He, R Huang… - Signal transduction and …, 2023 - nature.com
Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate.
The challenges of SCI repair include its complex pathological mechanisms and the …

Oxidative stress following spinal cord injury: From molecular mechanisms to therapeutic targets

M Yu, Z Wang, D Wang, M Aierxi, Z Ma… - Journal of …, 2023 - Wiley Online Library
Spinal cord injury (SCI) is a medical condition that results from severe trauma to the central
nervous system; it imposes great psychological and economic burdens on affected patients …

Exosomes derived from miR-133b-modified mesenchymal stem cells promote recovery after spinal cord injury

D Li, P Zhang, X Yao, H Li, H Shen, X Li… - Frontiers in …, 2018 - frontiersin.org
Dysregulation of microRNAs (miRNAs) has been found in injured spinal cords after spinal
cord injury (SCI). Previous studies have shown that miR-133b plays an important role in the …

Mitochondrial biogenesis as a therapeutic target for traumatic and neurodegenerative CNS diseases

EC Simmons, NE Scholpa, RG Schnellmann - Experimental neurology, 2020 - Elsevier
Central nervous system (CNS) diseases, both traumatic and neurodegenerative, are
characterized by impaired mitochondrial bioenergetics and often disturbed mitochondrial …

Cell death pathways: a novel therapeutic approach for neuroscientists

G Morris, AJ Walker, M Berk, M Maes, BK Puri - Molecular neurobiology, 2018 - Springer
In the first part, the following mechanisms involved in different forms of cell death are
considered, with a view to identifying potential therapeutic targets: tumour necrosis factor …

Minocycline targets multiple secondary injury mechanisms in traumatic spinal cord injury

RB Shultz, Y Zhong - Neural regeneration research, 2017 - journals.lww.com
Minocycline hydrochloride (MH), a semi-synthetic tetracycline derivative, is a clinically
available antibiotic and anti-inflammatory drug that also exhibits potent neuroprotective …

Mitochondrial-based therapeutics for the treatment of spinal cord injury: mitochondrial biogenesis as a potential pharmacological target

NE Scholpa, RG Schnellmann - Journal of Pharmacology and Experimental …, 2017 - ASPET
Spinal cord injury (SCI) is characterized by an initial trauma followed by a progressive
cascade of damage referred to as secondary injury. A hallmark of secondary injury is …

[HTML][HTML] Promising neuroprotective strategies for traumatic spinal cord injury with a focus on the differential effects among anatomical levels of injury

A Ulndreaj, A Badner, MG Fehlings - F1000Research, 2017 - ncbi.nlm.nih.gov
Traumatic spinal cord injury (SCI) is a devastating condition of motor, sensory, and
autonomic dysfunction. The significant cost associated with the management and lifetime …

An open‐label evaluator‐blinded clinical study of minocycline neuroprotection in ischemic stroke: gender‐dependent effect

MR Amiri‐Nikpour, S Nazarbaghi… - Acta Neurologica …, 2015 - Wiley Online Library
Objectives Minocycline as an antibiotic has been found to have neuroprotective effect on
neurodegenerative diseases. This study was aimed at determining the efficacy of …

Neuroprotective effects of minocycline on focal cerebral ischemia injury: a systematic review

Y Naderi, Y Panahi, GE Barreto… - Neural regeneration …, 2020 - journals.lww.com
To review the neuroprotective effects of minocycline in focal cerebral ischemia in animal
models. By searching in the databases of PubMed, ScienceDirect, and Scopus, and …