Astragalus Mongholicus: A review of its anti-fibrosis properties
F Gong, R Qu, Y Li, Y Lv, J Dai - Frontiers in Pharmacology, 2022 - frontiersin.org
Background: Fibrosis-related diseases (FRD) include cerebral fibrosis, pulmonary fibrosis,
cardiac fibrosis, liver fibrosis, renal fibrosis, peritoneal fibrosis, etc. The effects of fibrosis can …
cardiac fibrosis, liver fibrosis, renal fibrosis, peritoneal fibrosis, etc. The effects of fibrosis can …
Physiological and pathological factors affecting drug delivery to the brain by nanoparticles
The prevalence of neurological/neurodegenerative diseases, such as Alzheimer's disease is
known to be increasing due to an aging population and is anticipated to further grow in the …
known to be increasing due to an aging population and is anticipated to further grow in the …
Quadruple abnormal protein aggregates in brainstem pathology and exogenous metal-rich magnetic nanoparticles (and engineered Ti-rich nanorods). The substantia …
L Calderón-Garcidueñas, A González-Maciel… - Environmental …, 2020 - Elsevier
Fine particulate air pollution (PM 2.5) exposures are linked with Alzheimer's and Parkinson's
diseases (AD, PD). AD and PD neuropathological hallmarks are documented in children …
diseases (AD, PD). AD and PD neuropathological hallmarks are documented in children …
Bivalent metal ions induce formation of α-synuclein fibril polymorphs with different cytotoxicities
Abstract α-Synuclein (α-Syn) aggregates are key components of intracellular inclusion
bodies characteristic of Parkinson's disease (PD) and other synucleinopathies. Metal ions …
bodies characteristic of Parkinson's disease (PD) and other synucleinopathies. Metal ions …
Environmentally toxic solid nanoparticles in noradrenergic and dopaminergic nuclei and cerebellum of metropolitan Mexico City children and young adults with neural …
L Calderón-Garcidueñas, A González-Maciel… - Toxics, 2022 - mdpi.com
Quadruple aberrant hyperphosphorylated tau, beta-amyloid, α-synuclein and TDP-43
neuropathology and metal solid nanoparticles (NPs) are documented in the brains of …
neuropathology and metal solid nanoparticles (NPs) are documented in the brains of …
The investigation of interaction and chaperon-like activity of α-synuclein as a protein in pathophysiology of Parkinson's disease upon direct interaction with …
W Tu, C Zheng, Y Zheng, Z Feng, H Lin, Y Jiang… - International Journal of …, 2023 - Elsevier
Analyzing the therapeutic potential of a therapeutic biomolecule requires an understanding
of how it may interact with proteins and modify their corresponding functions. α-Synuclein is …
of how it may interact with proteins and modify their corresponding functions. α-Synuclein is …
Rapid on-site amplification and visual detection of misfolded proteins via microfluidic quaking-induced conversion (Micro-QuIC)
DJ Lee, PR Christenson, G Rowden, NC Lindquist… - npj Biosensing, 2024 - nature.com
Protein misfolding diseases, such as prion diseases, Alzheimer's, and Parkinson's, share a
common molecular mechanism involving the misfolding and aggregation of specific …
common molecular mechanism involving the misfolding and aggregation of specific …
Nanoparticle-enhanced RT-QuIC (nano-QuIC) diagnostic assay for misfolded proteins
Misfolded proteins associated with various neurodegenerative diseases often accumulate in
tissues or circulate in biological fluids years before the clinical onset, thus representing ideal …
tissues or circulate in biological fluids years before the clinical onset, thus representing ideal …
Syringic acid demonstrates promising protective effect against tau fibrillization and cytotoxicity through regulation of endoplasmic reticulum stress-mediated pathway …
X Li, X Zhang, R Xing, F Qi, J Dong, D Li, X Tian… - International Journal of …, 2021 - Elsevier
There are several studies reporting that different plant-based metabolites are potential
inhibitors of protein amyloid fibrillation. As chemical features of metabolites can regulate …
inhibitors of protein amyloid fibrillation. As chemical features of metabolites can regulate …
Parkinson's disease: a nanotheranostic approach targeting alpha-synuclein aggregation
FLG Zoey, M Palanivel, P Padmanabhan… - Frontiers in Cell and …, 2021 - frontiersin.org
Parkinson's disease (PD) is one of the most common neurodegenerative disorders that is
implicated in aging populations. As numerous developed nations are experiencing …
implicated in aging populations. As numerous developed nations are experiencing …