Osteoporosis is a common disease with a strong genetic component characterized by
reduced bone mass, defects in the microarchitecture of bone tissue, and an increased risk of …

Cartilage not only plays essential roles in skeletal development and growth during pre-and
postnatal stages but also serves to provide smooth movement of skeletons throughout life …

The domestic dog is becoming an increasingly valuable model species in medical genetics,
showing particular promise to advance our understanding of cancer and orthopaedic …

Mesenchymal stem cells (MSCs) arise from a variety of tissues, including bone marrow and
adipose tissue and, accordingly, have the potential to differentiate into multiple cell types …

Low-density lipoprotein-related receptors 5 and 6 (LRP5/6) are highly homologous proteins
with key functions in canonical Wnt signaling. Alterations in the genes encoding these …

Sclerostin, the product of the SOST gene, is a secreted inhibitor of Wnt signaling that is
produced by osteocytes to regulate bone formation. While it is often considered an osteocyte …

Background Osteoarthritis (OA) is a multifactorial disease characterized by destruction of the
articular cartilage due to environmental, mechanical and genetic components. The genetics …

Objective To determine genome‐wide methylation profiles of bone from patients with hip
osteoarthritis (OA) and those with osteoporotic (OP) hip fractures. Methods Trabecular bone …

Objective To assess candidate genes for association with osteoarthritis (OA) and identify
promising genetic factors and, secondarily, to assess the candidate gene approach in OA …

The relationship between osteoarthritis (OA) and osteoporosis (OP), the two most common
skeletal disorders related to aging, is controversial. Previous studies suggest that OA is …