Multiple sclerosis (MS) is the commonest non‐traumatic disabling disease to affect young
adults. The incidence of MS is increasing worldwide, together with the socioeconomic …

Ageing is a major risk factor for developing many neurodegenerative diseases. Cellular
senescence is a homeostatic biological process that has a key role in driving ageing. There …

Background Cortical disease has emerged as a critical aspect of the pathogenesis of
multiple sclerosis, being associated with disease progression and cognitive impairment …

Multiple sclerosis is characterized at the gross pathological level by the presence of
widespread focal demyelinating lesions of the myelin-rich white matter. However, it is …

Meningeal inflammation in the form of ectopic lymphoid-like structures has been suggested
to play a prominent role in the development of cerebral cortical grey matter pathology in …

Pathological evaluation is the gold standard for identifying processes related to multiple
sclerosis that explain disease manifestations, and for guiding the development of new …

MS is heterogeneous with respect to clinical, genetic, radiographic, and pathologic features;
surrogate MRI, clinical, genetic, serologic, and/or CSF markers for each of the four …

Multiple sclerosis (MS), is a chronic disease of the central nervous system (CNS)
characterized by loss of motor and sensory function, that results from immune-mediated …

The primary progressive form of multiple sclerosis is characterized by accrual of
neurological dysfunction from disease onset without remission and it is still a matter of …

Neuroaxonal pathology is a main determinant of disease progression in multiple sclerosis;
however, its underlying pathophysiological mechanisms, including its link to inflammatory …