The spatial segregation of the genome into compartments is a major feature of 3D genome
organization. New data on mammalian chromosome organization across different conditions …

White adipose tissue browning is a key metabolic process controlled by epigenetic factors
that facilitate changes in gene expression leading to altered cell identity. We find that male …

Intellectual disability is a well-known hallmark of Down Syndrome (DS) that results from the
triplication of the critical region of human chromosome 21 (HSA21). Major studies were …

Background Long-range interactions between promoters and cis-regulatory elements, such
as enhancers, play critical roles in gene regulation. However, the role of three-dimensional …

Dental enamel formation is coordinated by ameloblast differentiation, production of enamel
matrix proteins, and crystal growth. The factors regulating ameloblast differentiation are not …

Aging is a universal physiological phenomenon, and chronic age-related diseases have
become one of the leading causes of human mortality, accounting for nearly half of all …

Down syndrome (DS) is caused by the triplication of chromosome 21, but science is still
investigating the precise mechanisms by which this results in the various phenotypes, such …