Cytoplasmic dynein is a microtubule motor vital for cellular organization and division. It
functions as a~ 4-megadalton complex containing its cofactor dynactin and a cargo-specific …

Cytoplasmic dynein drives the motility and force generation functions towards the
microtubule minus end. The assembly of dynein with dynactin and a cargo adaptor in an …

The lissencephaly-related protein LIS1 is a critical regulator of cytoplasmic dynein that
governs motor function and intracellular localization (for example, to microtubule plus-ends) …

Cytoplasmic dynein-1 transports intracellular cargo towards microtubule minus ends. Dynein
is autoinhibited and undergoes conformational changes to form an active complex that …

Dynein is the primary minus-end-directed microtubule motor protein. To achieve activation,
dynein binds to the dynactin complex and an adaptor to form the" activated dynein complex." …

The functional significance of Kinesin-1 autoinhibition has been unclear. Kinesin-1
transports multiple cargoes including cytoplasmic dynein to microtubule plus ends. From a …

Lis1 is a key cofactor for the assembly of active cytoplasmic dynein complexes that transport
cargo along microtubules. Lis1 binds to the AAA+ ring and stalk of dynein and slows dynein …

Microtubule motors, like cytoplasmic dynein-1, are tightly regulated to prevent inappropriate
activity in cells. Dynein functions as a~ 4 MDa complex containing its cofactor dynactin and a …

The microtubule motor dynein is regulated by lissencephaly-1 (Lis1) at several points during
its complex activation process. Two papers reveal the molecular mechanism for two steps …

Aims Cytoplasmic dynein heavy chain (DYNC1H1) is a multi-subunit protein complex that
provides motor force for movement of cargo on microtubules and traffics them back to the …