Alzheimer's disease (AD) is the most common form of dementia. AD brain pathology starts
decades before the onset of clinical symptoms. One early pathological hallmark is blood …

Spinal cord injury (SCI) is a devastating and disabling medical condition generally caused
by a traumatic event (primary injury). This initial trauma is accompanied by a set of biological …

Background Alterations in the brain cortical structures of patients with chronic kidney
disease (CKD) have been reported; however, the cause has not been determined yet …

Neuropsychiatric conditions including depression, anxiety disorders, and cognitive
impairment are prevalent in patients with chronic kidney disease (CKD). These conditions …

This comprehensive narrative review explores the concept of neuro-vulnerability in energy
metabolism regulation and its implications for metabolic disorders. The review highlights the …

Emerging evidence indicates that the dysregulation of cellular redox homeostasis and
chronic inflammatory processes are implicated in the pathogenesis of kidney and brain …

Metabolic acidosis, defined as a plasma or serum bicarbonate concentration< 22 mmol/L, is
a frequent consequence of chronic kidney disease (CKD) and occurs in~ 10–30% of …

Kidney dysfunction can profoundly influence many organ systems, and recent evidence
suggests a potential role for increased albuminuria in the development of mild cognitive …

Patients with chronic kidney disease (CKD) have an increased risk of both ischaemic and
haemorrhagic stroke compared with the general population. Both acute and chronic kidney …

Background Association between kidney dysfunction and dementia has been studied in
western cohorts, but with inconsistent conclusions which may be due to the different …