Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts
Pluripotent stem cells provide a potential solution to current epidemic rates of heart failure by
providing human cardiomyocytes to support heart regeneration. Studies of human …
providing human cardiomyocytes to support heart regeneration. Studies of human …
Integrated approaches to spatiotemporally directing angiogenesis in host and engineered tissues
RJ Kant, KLK Coulombe - Acta biomaterialia, 2018 - Elsevier
The field of tissue engineering has turned towards biomimicry to solve the problem of tissue
oxygenation and nutrient/waste exchange through the development of vasculature …
oxygenation and nutrient/waste exchange through the development of vasculature …
Heart regeneration with engineered myocardial tissue
KLK Coulombe, VK Bajpai… - Annual review of …, 2014 - annualreviews.org
Heart disease is the leading cause of morbidity and mortality worldwide, and regenerative
therapies that replace damaged myocardium could benefit millions of patients annually. The …
therapies that replace damaged myocardium could benefit millions of patients annually. The …
[HTML][HTML] An injectable oxygen release system to augment cell survival and promote cardiac repair following myocardial infarction
Oxygen deficiency after myocardial infarction (MI) leads to massive cardiac cell death.
Protection of cardiac cells and promotion of cardiac repair are key therapeutic goals. These …
Protection of cardiac cells and promotion of cardiac repair are key therapeutic goals. These …
Oxygen releasing and antioxidant breathing cardiac patch delivering exosomes promotes heart repair after myocardial infarction
Constant oxygen supply is inevitable for cardiac tissue function and survival. Myocardial
infarction (MI) leaves heart tissue in a state of oxygen deficiency, causing oxidative stress …
infarction (MI) leaves heart tissue in a state of oxygen deficiency, causing oxidative stress …
Pluripotent stem cell derived cardiomyocytes for cardiac repair
Opinion statement The adult mammalian heart has limited capacity for regeneration, and
any major injury such as a myocardial infarction results in the permanent loss of up to 1 …
any major injury such as a myocardial infarction results in the permanent loss of up to 1 …
Myocardial ischemia and its complications
GA Fishbein, MC Fishbein, J Wang, LM Buja - Cardiovascular pathology, 2022 - Elsevier
Atherosclerotic cardiovascular disease is the number one killer of both men and women in
industrialized countries. Occlusion of the arteries to the heart, the coronary arteries, leads to …
industrialized countries. Occlusion of the arteries to the heart, the coronary arteries, leads to …
[HTML][HTML] Optical mapping of human embryonic stem cell-derived cardiomyocyte graft electrical activity in injured hearts
Background Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) show
tremendous promise for cardiac regeneration, but the successful development of hESC-CM …
tremendous promise for cardiac regeneration, but the successful development of hESC-CM …
[HTML][HTML] Patterned Arteriole-Scale Vessels Enhance Engraftment, Perfusion, and Vessel Branching Hierarchy of Engineered Human Myocardium for Heart …
Heart regeneration after myocardial infarction (MI) using human stem cell-derived
cardiomyocytes (CMs) is rapidly accelerating with large animal and human clinical trials …
cardiomyocytes (CMs) is rapidly accelerating with large animal and human clinical trials …
[HTML][HTML] New vessel formation in the context of cardiomyocyte regeneration–the role and importance of an adequate perfusing vasculature
KC Michelis, M Boehm, JC Kovacic - Stem cell research, 2014 - Elsevier
The history of revascularization for cardiac ischemia dates back to the early 1960's when the
first coronary artery bypass graft procedures were performed in humans. With this 50 year …
first coronary artery bypass graft procedures were performed in humans. With this 50 year …