Liver cancer ranks the sixth in cancer incidence and the second in tumor related mortality
worldwide, with over half of the new cases and deaths occur in China. Because of difficulties …

Tissue fibrosis is a pathological condition that is associated with impaired epithelial repair
and excessive deposition of extracellular matrix (ECM). Fibrotic lesions increase the risk of …

Liver cancer is the second leading cause of cancer‐related deaths, and hepatocellular
carcinoma (HCC) is the most common type. Therefore, molecular targets are urgently …

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, which
ranks as the sixth of cancer-related death. Despite the emergence of targeted therapy …

Activation of hepatic stellate cells (HSCs) represents the primary driving force to promote the
progression of chronic cholestatic liver diseases. We previously reported that cholangiocyte …

Mouse models are the basis of preclinical and translational research in hepatocellular
carcinoma (HCC). Multiple methods exist to induce tumour formation in mice, including …

Purpose: The aim of our study is to elucidate whether T cells expressing GPC3-targeted
chimeric antigen receptor (CAR) can efficiently eliminate GPC3-positive HCC cells and their …

Background and Aims Glypican 3 (GPC3) is an oncofetal antigen involved in Wnt-dependent
cell proliferation that is highly expressed in hepatocellular carcinoma (HCC). We …

Glypican-3 (GPC3) is a membrane-associated proteoglycan that is specifically up-regulated
in hepatocellular carcinoma (HCC) although rarely or not expressed in normal liver tissues …

Liver cancer is the second leading cause of cancer-related deaths worldwide, and
hepatocellular carcinoma is the most common type. The pathogenesis of hepatocellular …