Worldwide, bacterial resistance to chemical antibiotics has reached such a high level that
endangers public health. Presently, the adoption of alternative strategies that promote the …

Bacterial Vaginosis (BV) is a complex polymicrobial infection of vagina that shifts the
paradigms of vaginal flora from lactobacilli to opportunistic pathogens. BV is catagorized by …

Lysins represent a novel class of anti-infectives derived from bacteriophage. Lysins are
bacterial cell-wall hydrolytic enzymes that selectively and rapidly kill (≥ 3 log cfu in 30 min) …

Background Staphylococcus aureus is a major cause of healthcare associated mortality, but
like many important bacterial pathogens, it is a common constituent of the normal human …

Since the advent of penicillin, humans have known about and explored the phenomenon of
bacterial inhibition via antibiotics. However, with changes in the global environment and the …

Most bacteriophages encode two types of cell wall lytic proteins: endolysins (lysins) and
virion-associated peptidoglycan hydrolases. Both enzymes have the ability to degrade the …

We describe a novel approach for screening fragments against a protein that combines the
sensitivity of DNA-encoded library technology with the ability of fragments to explore what …

The emerging occurrence of antibiotic-resistant bacterial pathogens leads to a recollection
of bacteriophage as antimicrobial therapeutics. This article presents a short overview of the …

Direct lytic agents (DLAs) are novel antimicrobial compounds with unique mechanisms of
action based on rapid cell wall destabilization and bacteriolysis. DLAs include two classes of …

Highlights•Multidrug-resistant infections have sparked a renewed interest in
bacteriophages.•Synthetic biology has enabled technologies for next-generation phage …