Diabetes mellitus and Alzheimer's disease: GSK-3β as a potential link
Y Zhang, N Huang, F Yan, H Jin, S Zhou, J Shi… - Behavioural brain …, 2018 - Elsevier
It is well known that Alzheimer's disease (AD) is closely related to diabetes mellitus (DM),
and AD is also regarded as Type 3 diabetes (T3D). However, the exact link between AD and …
and AD is also regarded as Type 3 diabetes (T3D). However, the exact link between AD and …
[HTML][HTML] Challenges for Alzheimer's disease therapy: insights from novel mechanisms beyond memory defects
Alzheimer's disease (AD), the most common form of dementia in late life, will become even
more prevalent by midcentury, constituting a major global health concern with huge …
more prevalent by midcentury, constituting a major global health concern with huge …
Gut microbiota regulate Alzheimer's disease pathologies and cognitive disorders via PUFA-associated neuroinflammation
Objective This study is to investigate the role of gut dysbiosis in triggering inflammation in
the brain and its contribution to Alzheimer's disease (AD) pathogenesis. Design We …
the brain and its contribution to Alzheimer's disease (AD) pathogenesis. Design We …
Systematic phenotyping and characterization of the 3xTg-AD mouse model of Alzheimer's disease
DI Javonillo, KM Tran, J Phan, E Hingco… - Frontiers in …, 2022 - frontiersin.org
Animal models of disease are valuable resources for investigating pathogenic mechanisms
and potential therapeutic interventions. However, for complex disorders such as Alzheimer's …
and potential therapeutic interventions. However, for complex disorders such as Alzheimer's …
The link between type 2 diabetes and neurodegeneration: roles for amyloid-β, amylin, and tau proteins
P Bharadwaj, N Wijesekara… - Journal of …, 2017 - content.iospress.com
A wealth of evidence indicates a strong link between type 2 diabetes (T2D) and
neurodegenerative diseases such as Alzheimer's disease (AD). Although the precise …
neurodegenerative diseases such as Alzheimer's disease (AD). Although the precise …
Cerebrovascular insulin receptors are defective in Alzheimer's disease
M Leclerc, P Bourassa, C Tremblay, V Caron, C Sugère… - Brain, 2023 - academic.oup.com
Central response to insulin is suspected to be defective in Alzheimer's disease. As most
insulin is secreted in the bloodstream by the pancreas, its capacity to regulate brain …
insulin is secreted in the bloodstream by the pancreas, its capacity to regulate brain …
From obesity to hippocampal neurodegeneration: pathogenesis and non-pharmacological interventions
TH Lee, S Yau - International journal of molecular sciences, 2020 - mdpi.com
High-caloric diet and physical inactivity predispose individuals to obesity and diabetes,
which are risk factors of hippocampal neurodegeneration and cognitive deficits. Along with …
which are risk factors of hippocampal neurodegeneration and cognitive deficits. Along with …
Cognitive dysfunction: a growing link between diabetes and Alzheimer's disease
K Jash, P Gondaliya, P Kirave… - Drug development …, 2020 - Wiley Online Library
Diabetes mellitus (DM) is a gradually rising metabolic disease which is currently affecting
millions of people worldwide. Diabetes is associated with various complications like …
millions of people worldwide. Diabetes is associated with various complications like …
The bile acid TUDCA improves glucose metabolism in streptozotocin-induced Alzheimer's disease mice model
L Zangerolamo, JF Vettorazzi, C Solon… - Molecular and Cellular …, 2021 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder and the major cause of dementia.
According to predictions of the World Health Organization, more than 150 million people …
According to predictions of the World Health Organization, more than 150 million people …
Amyloid‐β and islet amyloid pathologies link Alzheimer's disease and type 2 diabetes in a transgenic model
N Wijesekara, R Ahrens, M Sabale, L Wu… - The FASEB …, 2017 - Wiley Online Library
Alzheimer's disease (AD) and type 2 diabetes (T2D) present a significant risk to each other.
AD and T2D are characterized by deposition of cerebral amyloid‐β (Aβ) and pancreatic …
AD and T2D are characterized by deposition of cerebral amyloid‐β (Aβ) and pancreatic …