Vascular dysfunction in preeclampsia

MA Opichka, MW Rappelt, DD Gutterman, JL Grobe… - Cells, 2021 - mdpi.com
Preeclampsia is a life-threatening pregnancy-associated cardiovascular disorder
characterized by hypertension and proteinuria at 20 weeks of gestation. Though its exact …

Endometrial receptivity in women of advanced age: an underrated factor in infertility

ADS Pathare, M Loid, M Saare, SB Gidlöf… - Human reproduction …, 2023 - academic.oup.com
BACKGROUND Modern lifestyle has led to an increase in the age at conception. Advanced
age is one of the critical risk factors for female-related infertility. It is well known that maternal …

[HTML][HTML] BaP/BPDE suppressed endothelial cell angiogenesis to induce miscarriage by promoting MARCHF1/GPX4-mediated ferroptosis

Y Zhang, Y Yang, W Chen, C Mi, X Xu, Y Shen… - Environment …, 2023 - Elsevier
Environmental benzo (a) pyrene (BaP) and its ultimate metabolite BPDE (benzo (a) pyrene-
7, 8-dihydrodiol-9, 10-epoxide) are universal and inevitable persistent organic pollutants …

Stromal cell senescence contributes to impaired endometrial decidualization and defective interaction with trophoblast cells

PI Deryabin, AV Borodkina - Human Reproduction, 2022 - academic.oup.com
STUDY QUESTION What are the consequences of endometrial stromal cell (EnSC)
senescence for endometrial function? SUMMARY ANSWER Senescence of EnSC …

TRIM28 modulates nuclear receptor signaling to regulate uterine function

R Li, T Wang, RM Marquardt, JP Lydon, SP Wu… - Nature …, 2023 - nature.com
Estrogen and progesterone, acting through their cognate receptors the estrogen receptor α
(ERα) and the progesterone receptor (PR) respectively, regulate uterine biology. Using rapid …

The role of interleukins in recurrent implantation failure: a comprehensive review of the literature

K Pantos, S Grigoriadis, E Maziotis, K Pistola… - International journal of …, 2022 - mdpi.com
Recurrent implantation failure (RIF) is a multifactorial condition affecting 10–15% of in vitro
fertilization (IVF) couples. Data suggest that functional dysregulation of the endometrial …

Uterine natural killer cells: A rising star in human pregnancy regulation

M Xie, Y Li, YZ Meng, P Xu, YG Yang, S Dong… - Frontiers in …, 2022 - frontiersin.org
Uterine natural killer (uNK) cells are an immune subset located in the uterus. uNK cells have
distinct tissue-specific characteristics compared to their counterparts in peripheral blood and …

Maternal IL-33 critically regulates tissue remodeling and type 2 immune responses in the uterus during early pregnancy in mice

N Valero-Pacheco, EK Tang, N Massri… - Proceedings of the …, 2022 - National Acad Sciences
The pregnant uterus is an immunologically rich organ, with dynamic changes in the
inflammatory milieu and immune cell function underlying key stages of pregnancy. Recent …

Progesterone receptor signaling in the uterus is essential for pregnancy success

DI Cope, D Monsivais - Cells, 2022 - mdpi.com
The uterus plays an essential role in the reproductive health of women and controls critical
processes such as embryo implantation, placental development, parturition, and …

Preeclampsia: from cellular wellness to inappropriate cell death, and the roles of nutrition

AW Lokeswara, R Hiksas, R Irwinda… - Frontiers in Cell and …, 2021 - frontiersin.org
Preeclampsia is one of the most common obstetrical complications worldwide. The
pathomechanism of this disease begins with abnormal placentation in early pregnancy …