Autophagy is a conserved lysosomal pathway for the degradation of cytoplasmic
components. Basal autophagy in kidney cells is essential for the maintenance of kidney …

Increasing oxidative stress, a major characteristic of aging, has been implicated in a variety
of age-related pathologies. In aging, oxidant production from several sources is increased …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

The renal condition is one of the crucial predictors of longevity; therefore, early diagnosis of
any dysfunction plays an important role. Kidneys are highly susceptible to the aging process …

Autophagy is a highly conserved process that degrades cellular long-lived proteins and
organelles. Accumulating evidence indicates that autophagy plays a critical role in kidney …

Polyamines, spermidine and spermine, are synthesized in every living cell and are therefore
contained in foods, especially in those that are thought to contribute to health and longevity …

Autophagy is essential in regulating the turnover of macromolecules via removing damaged
organelles, misfolded proteins in various tissues, including liver, skeletal muscles, and …

Autophagy, a major catabolic pathway responsible of the elimination of damaged proteins
and organelles, is now recognized as an anti-aging process. In addition to its basal role in …

Three decades have passed since a series of studies indicated that the aging kidney was
characterized by increased susceptibility to nephrotoxic injury. Data from these experimental …

Renal fibrosis is the final common pathway of all chronic kidney diseases progressing to end-
stage renal diseases. Autophagy, a highly conserved lysosomal degradation pathway, plays …