The hypothalamus-pituitary-gonad axis: tales of mice and men

A Kaprara, IT Huhtaniemi - Metabolism, 2018 - Elsevier
Reproduction is controlled by the hypothalamic-pituitary-gonadal (HPG) axis. Gonadotropin-
releasing hormone (GnRH) neurons play a central role in this axis through production of …

Regulation of FGF signaling: Recent insights from studying positive and negative modulators

L Korsensky, D Ron - Seminars in Cell & Developmental Biology, 2016 - Elsevier
Fibroblast growth factor (FGF) signaling is involved in a multitude of biological processes,
while impairment of FGF signaling is implicated in a variety of human diseases including …

Functional heterogeneity of mouse and human brain OPCs: relevance for preclinical studies in multiple sclerosis

A Bribián, EM Medina-Rodríguez, F Josa-Prado… - Journal of Clinical …, 2020 - mdpi.com
Besides giving rise to oligodendrocytes (the only myelin-forming cell in the Central Nervous
System (CNS) in physiological conditions), Oligodendrocyte Precursor Cells (OPCs) are …

Novel microdeletion in the X chromosome leads to Kallmann syndrome, ichthyosis, obesity, and strabismus

W Ma, J Mao, X Wang, L Duan, Y Song, X Lian… - Frontiers in …, 2020 - frontiersin.org
Background A large deletion in Xp22. 3 can result in contiguous gene syndromes, including
X-linked ichthyosis (XLI) and Kallmann syndrome (KS), presenting with short stature …

Anosmin-1 over-expression regulates oligodendrocyte precursor cell proliferation, migration and myelin sheath thickness

V Murcia-Belmonte, PF Esteban… - Brain Structure and …, 2016 - Springer
During development of the central nervous system, anosmin-1 (A1) works as a chemotropic
cue contributing to axonal outgrowth and collateralization, as well as modulating the …

[图书][B] Гонадотропины–от теории к клинической практике

АО Шпаков - 2018 - elibrary.ru
В монографии рассмотрены структурно-функциональная организация гонадотропинов–
фолликулостимулирующего и лютеинизирующего гормонов и различных изоформ …

Anosmin 1 N-terminal domains modulate prokineticin receptor 2 activation by prokineticin 2

V Murcia-Belmonte, M Tercero-Díaz, D Barrasa-Martín… - Cellular …, 2022 - Elsevier
The X-linked form of Kallmann syndrome (KS), characterized by hypogonadotropic
hypogonadism and anosmia, is due to mutations in the ANOS1 gene that encodes for the …

Anosmin-1 over-expression increases adult neurogenesis in the subventricular zone and neuroblast migration to the olfactory bulb

D García-González, V Murcia-Belmonte… - Brain Structure and …, 2016 - Springer
New subventricular zone (SVZ)-derived neuroblasts that migrate via the rostral migratory
stream are continuously added to the olfactory bulb (OB) of the adult rodent brain. Anosmin …

Olfactory system and demyelination

D Garcia‐Gonzalez, V Murcia‐Belmonte… - The Anatomical …, 2013 - Wiley Online Library
Within the central nervous system, the olfactory system represents one of the most exciting
scenarios since it presents relevant examples of long‐life sustained neurogenesis and …

ERK1/2 signaling is essential for the chemoattraction exerted by human FGF2 and human anosmin‐1 on newborn rat and mouse OPCs via FGFR1

V Murcia‐Belmonte, EM Medina‐Rodríguez, A Bribián… - Glia, 2014 - Wiley Online Library
Signaling through fibroblast growth factor receptors (FGFRs) is essential for many cellular
processes including proliferation and migration, as well as differentiation events such as …