Relapse to drug use during abstinence is a defining feature of addiction. During the last
several decades, this clinical scenario has been studied at the preclinical level using classic …

Although it is challenging for individuals with cocaine addiction to achieve abstinence, the
greatest difficulty is avoiding relapse to drug taking, which is often triggered by cues …

In recent years, animal models in psychiatric research have been criticized for their limited
translational value to the clinical situation. Failures in clinical trials have thus often been …

High rates of relapse to drug use during abstinence is a defining feature of drug addiction. In
abstinent drug users, drug relapse is often precipitated by acute exposure to the self …

The last two decades have witnessed substantial advances in identifying synaptic plasticity
responsible for behavioral changes in animal models of substance use disorder. We have …

High rates of relapse to drug use during abstinence is a defining feature of human drug
addiction. This clinical scenario has been studied at the preclinical level using different …

Importance A common trigger for relapse in drug addiction is the experience of craving via
exposure to cues previously associated with drug use. Preclinical studies have consistently …

Lifetime relapse rates remain a major obstacle in addressing the current opioid crisis.
Relapse to opioid use can be modeled in rodent studies where drug self-administration is …

Previous studies both in laboratory animals and humans have reported that abstinence
induces incubation of cue-induced drug craving for nicotine, alcohol, cocaine, and …

It was suggested in 1986 that cue-induced cocaine craving increases progressively during
early abstinence and remains high during extended periods of time. Clinical evidence now …