Short-read, high-throughput sequencing (HTS) methods have yielded numerous important
insights into microbial ecology and function. Yet, in many instances short-read HTS …

Since its introduction, nanopore sequencing has enhanced our ability to study complex
microbial samples through the possibility to sequence long reads in real time using …

Antibiotics are deployed against bacterial pathogens, but their targeting of conserved
microbial processes means they also collaterally perturb the commensal microbiome. To …

The ongoing global novel coronavirus pneumonia COVID‐19 outbreak has engendered
numerous cases of infection and death. COVID‐19 diagnosis relies upon nucleic acid …

Background Species-level genetic characterization of complex bacterial communities has
important clinical applications in both diagnosis and treatment. Amplicon sequencing of the …

Adaptive sampling is a method of software-controlled enrichment unique to nanopore
sequencing platforms. To test its potential for enrichment of rarer species within …

The innate immune system is the oldest protection strategy that is conserved across all
organisms. Although having an unspecific action, it is the first and fastest defense …

Perturbations to the infant gut microbiome during the first weeks to months of life affect
growth, development and health. In particular, assembly of an altered intestinal microbiota …

Supplementation with members of the early-life microbiota as" probiotics" is increasingly
used in attempts to beneficially manipulate the preterm infant gut microbiota. We performed …

Bacterial bloodstream infections (BSIs) resulting in late-onset sepsis affect up to half of
extremely preterm infants and have substantial morbidity and mortality. Bacterial species …