The UDP-glucuronosyltransferases: their role in drug metabolism and detoxification
Human UDP-glucuronosyltransferase (UGT) exists as a superfamily of 22 proteins, which
are divided into 5 families and 6 subfamilies on the basis of sequence identity. Members of …
are divided into 5 families and 6 subfamilies on the basis of sequence identity. Members of …
Human UDP-glucuronosyltransferases: metabolism, expression, and disease
RH Tukey, CP Strassburg - Annual review of pharmacology and …, 2000 - annualreviews.org
In vertebrates, the glucuronidation of small lipophilic agents is catalyzed by the endoplasmic
reticulum UDP-glucuronosyltransferases (UGTs). This metabolic pathway leads to the …
reticulum UDP-glucuronosyltransferases (UGTs). This metabolic pathway leads to the …
[图书][B] Hayes' principles and methods of toxicology
AW Hayes, T Kobets - 2023 - taylorfrancis.com
Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …
informative reference for the concepts, methodologies, and assessments integral to …
Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios
JA Williams, R Hyland, BC Jones, DA Smith… - Drug Metabolism and …, 2004 - ASPET
Glucuronidation is a listed clearance mechanism for 1 in 10 of the top 200 prescribed drugs.
The objective of this article is to encourage those studying ligand interactions with UDP …
The objective of this article is to encourage those studying ligand interactions with UDP …
Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor
P Fernandez-Salguero, T Pineau, DM Hilbert… - Science, 1995 - science.org
The aryl hydrocarbon (Ah) receptor (AHR) mediates many carcinogenic and teratogenic
effects of environmentally toxic chemicals such as dioxin. An AHR-deficient (Ahr-/-) mouse …
effects of environmentally toxic chemicals such as dioxin. An AHR-deficient (Ahr-/-) mouse …
Cytochrome P4502C9: an enzyme of major importance in human drug metabolism
JO Miners, DJ Birkett - British journal of clinical pharmacology, 1998 - Wiley Online Library
Accumulating evidence indicates that CYP2C9 ranks amongst the most important drug
metabolizing enzymes in humans. Substrates for CYP2C9 include fluoxetine, losartan …
metabolizing enzymes in humans. Substrates for CYP2C9 include fluoxetine, losartan …
Cytochrome P450 3A: ontogeny and drug disposition
The maturation of organ systems during fetal life and childhood exerts a profound effect on
drug disposition. The maturation of drug-metabolising enzymes is probably the predominant …
drug disposition. The maturation of drug-metabolising enzymes is probably the predominant …
Glucosinolates in crop plants
EAS Rosa, RK Heaney, GR Fenwick… - Horticultural …, 2010 - books.google.com
Glucosinolates in crop plants Page 116 Glucosinolates in Crop Plants EAS Rosa Horticulture
Section Universidade de Trás-os-Montes e Alto Douro Vila Real, Portugal RK Heaney and …
Section Universidade de Trás-os-Montes e Alto Douro Vila Real, Portugal RK Heaney and …
Pharmacogenomics of human UDP-glucuronosyltransferase enzymes
C Guillemette - The pharmacogenomics journal, 2003 - nature.com
ABSTRACT UDP-glucuronosyltransferase (UGT) enzymes comprise a superfamily of key
proteins that catalyze the glucuronidation reaction on a wide range of structurally diverse …
proteins that catalyze the glucuronidation reaction on a wide range of structurally diverse …
Pharmacokinetics and dosage adjustment in patients with renal dysfunction
RK Verbeeck, FT Musuamba - European journal of clinical pharmacology, 2009 - Springer
Introduction Chronic kidney disease is a common, progressive illness that is becoming a
global public health problem. In patients with kidney dysfunction, the renal excretion of …
global public health problem. In patients with kidney dysfunction, the renal excretion of …