Structure and function of microbial α-l-fucosidases: a mini review
Fucose is a monosaccharide commonly found in mammalian, insect, microbial and plant
glycans. The removal of terminal α-l-fucosyl residues from oligosaccharides and …
glycans. The removal of terminal α-l-fucosyl residues from oligosaccharides and …
[HTML][HTML] Highly-sensitive label-free deep profiling of N-glycans released from biomedically-relevant samples
Alterations of protein glycosylation can serve as sensitive and specific disease biomarkers.
Labeling procedures for improved separation and detectability of oligosaccharides have …
Labeling procedures for improved separation and detectability of oligosaccharides have …
[HTML][HTML] Twelve years of genome-wide association studies of human protein N-glycosylation
A Timoshchuk, S Sharapov, YS Aulchenko - Engineering, 2023 - Elsevier
Most human-secreted and membrane-bound proteins have covalently attached
oligosaccharide chains or glycans. Glycosylation influences the physical and chemical …
oligosaccharide chains or glycans. Glycosylation influences the physical and chemical …
[HTML][HTML] Deep learning explains the biology of branched glycans from single-cell sequencing data
Glycosylation is ubiquitous and often dysregulated in disease. However, the regulation and
functional significance of various types of glycosylation at cellular levels is hard to unravel …
functional significance of various types of glycosylation at cellular levels is hard to unravel …
Sialic Acid Derivatization of Fluorescently Labeled N-Glycans Allows Linkage Differentiation by Reversed-Phase Liquid Chromatography–Fluorescence Detection …
AB Moran, RA Gardner, M Wuhrer… - Analytical …, 2022 - ACS Publications
Sialic acids have diverse biological roles, ranging from promoting up to preventing protein
and cellular recognition in health and disease. The various functions of these …
and cellular recognition in health and disease. The various functions of these …
[HTML][HTML] Susceptibility of human plasma N-glycome to low-calorie and different weight-maintenance diets
Aberrant plasma protein glycosylation is associated with a wide range of diseases, including
diabetes, cardiovascular, and immunological disorders. To investigate plasma protein …
diabetes, cardiovascular, and immunological disorders. To investigate plasma protein …
Development of an exoglycosidase plate-based assay for detecting α1-3, 4 fucosylation biomarker in individuals with HNF1A-MODY
D Demus, PA Urbanowicz, RA Gardner, H Wu… - …, 2022 - academic.oup.com
Maturity-onset diabetes of the young due to hepatocyte nuclear factor-1 alpha variants
(HNF1A-MODY) causes monogenic diabetes. Individuals carrying damaging variants in …
(HNF1A-MODY) causes monogenic diabetes. Individuals carrying damaging variants in …
Serum metabolomics identified metabolite biomarkers and distinguished maturity-onset diabetes of the young from type 1 diabetes in the Chinese population
J Liu, J Fu, Z Xie, L Ding, D Wang, M Yu, Q Zhang… - Clinica Chimica …, 2023 - Elsevier
Background Maturity-onset diabetes of the young (MODY) patients have unique clinical
manifestations and need individualized treatments. We identified novel serum metabolic …
manifestations and need individualized treatments. We identified novel serum metabolic …
Clinical Manifestations and Biomarkers of the Maturity-Onset Diabetes of the Young.
İ Satman - Endocrinology Research & Practice, 2023 - search.ebscohost.com
Maturity-onset diabetes of the young is the most common monogenic diabetes form affecting
between 1% and 5% of all diabetes cases. Clinical characteristics include young onset …
between 1% and 5% of all diabetes cases. Clinical characteristics include young onset …
Fucosylated Proteins as Cancer Biomarkers
E Miyoshi, K Fujita, K Morishita, T Ouchida… - Glycosignals in Cancer …, 2023 - Springer
Fucosylation, a type of glycosylation associated with cancer and inflammation, involves the
attachment of fucose residues to glycans. Fucosylation is regulated by the expression of …
attachment of fucose residues to glycans. Fucosylation is regulated by the expression of …