Fucose is a monosaccharide commonly found in mammalian, insect, microbial and plant
glycans. The removal of terminal α-l-fucosyl residues from oligosaccharides and …

Alterations of protein glycosylation can serve as sensitive and specific disease biomarkers.
Labeling procedures for improved separation and detectability of oligosaccharides have …

Most human-secreted and membrane-bound proteins have covalently attached
oligosaccharide chains or glycans. Glycosylation influences the physical and chemical …

Glycosylation is ubiquitous and often dysregulated in disease. However, the regulation and
functional significance of various types of glycosylation at cellular levels is hard to unravel …

Sialic acids have diverse biological roles, ranging from promoting up to preventing protein
and cellular recognition in health and disease. The various functions of these …

Aberrant plasma protein glycosylation is associated with a wide range of diseases, including
diabetes, cardiovascular, and immunological disorders. To investigate plasma protein …

Maturity-onset diabetes of the young due to hepatocyte nuclear factor-1 alpha variants
(HNF1A-MODY) causes monogenic diabetes. Individuals carrying damaging variants in …

Background Maturity-onset diabetes of the young (MODY) patients have unique clinical
manifestations and need individualized treatments. We identified novel serum metabolic …

Maturity-onset diabetes of the young is the most common monogenic diabetes form affecting
between 1% and 5% of all diabetes cases. Clinical characteristics include young onset …

Fucosylation, a type of glycosylation associated with cancer and inflammation, involves the
attachment of fucose residues to glycans. Fucosylation is regulated by the expression of …