Angiogenesis is one of the hallmarks of cancer. Several studies have shown that vascular
endothelium growth factor (VEGF) plays a leading role in angiogenesis progression …

Great interest is presently given to the analysis of metabolic changes that take place
specifically in cancer cells. In this review we summarize the alterations in glycolysis …

Targeted therapies are designed to interfere with specific aberrant biologic pathways
involved in tumor development. The main classes of novel oncologic drugs include …

Wegener granulomatosis is a rare disease of unknown aetiology. In the majority of these
patients the kidney is involved in the disease process. We performed a case-control study to …

Purpose: The mTOR pathway is frequently activated in ovarian cancers. mTOR inhibitors,
such as everolimus, can reduce VEGF-A production by cancer cells. We investigated …

Functional imaging of solid tumors with positron emission tomography (PET) imaging is an
evolving field with continuous development of new PET tracers and discovery of new …

This study revisited 18 F-fluorodeoxyglucose (18 F-FDG) uptake and its relationship to
hypoxia in various tumor models. METHODS: We generated peritoneal carcinomatosis and …

The positron emission tomography (PET) tracer 3'-deoxy-3'-[18 F] fluorothymidine ([18 F]
FLT) has been proposed to measure cell proliferation non-invasively in vivo. Hence, it …

Background Effective chemotherapy rapidly reduces the spin–lattice relaxation of water
protons (T 1) in solid tumours and this change (ΔT 1) often precedes and strongly correlates …

Systems Biology holds that complex cellular functions are generated as system-level
properties endowed with robustness, each involving large networks of molecular …