A new era of plant biochemistry at the systems level is emerging, providing detailed
descriptions of biochemical phenomena at the cellular and organismal level. This new era is …

Metabolic networks are regulated to ensure the dynamic adaptation of biochemical reaction
fluxes to maintain cell homeostasis and optimal metabolic fitness in response to …

We lay the foundation of a circuit theory for chemical reaction networks. Chemical reactions
are grouped into chemical modules solely characterized by their current-concentration …

Microbes may maximize the number of daughter cells per time or per amount of nutrients
consumed. These two strategies correspond, respectively, to the use of enzyme-efficient or …

Elementary flux modes (EFMs) emerged as a formal concept to describe metabolic
pathways and have become an established tool for constraint-based modeling and …

Cyclophosphamide (CP), a chemotherapeutic agent, is restricted due to its side effects,
especially hepatotoxicity. Ginseng has often been clinically used with CP in China, but …

Acute kidney injury (AKI) is a severe and frequent condition in hospitalized patients.
Currently, no efficient therapy of AKI is available. Therefore, efforts focus on early prevention …

The chemolithotroph Cupriavidus necator H16 is known as a natural producer of the
bioplastic-polymer PHB, as well as for its metabolic versatility to utilize different substrates …

Metabolic modelling has entered a mature phase with dozens of methods and software
implementations available to the practitioner and the theoretician. It is not easy for a …

Highlights•Thermodynamic analyses reveal energy yield versus enzyme burden
tradeoffs.•Near-equilibrium reactions have spare enzyme capacity that allows rapid flux …