[HTML][HTML] limma powers differential expression analyses for RNA-sequencing and microarray studies
Abstract limma is an R/Bioconductor software package that provides an integrated solution
for analysing data from gene expression experiments. It contains rich features for handling …
for analysing data from gene expression experiments. It contains rich features for handling …
Computational models for lncRNA function prediction and functional similarity calculation
From transcriptional noise to dark matter of biology, the rapidly changing view of long non-
coding RNA (lncRNA) leads to deep understanding of human complex diseases induced by …
coding RNA (lncRNA) leads to deep understanding of human complex diseases induced by …
muscat detects subpopulation-specific state transitions from multi-sample multi-condition single-cell transcriptomics data
Single-cell RNA sequencing (scRNA-seq) has become an empowering technology to profile
the transcriptomes of individual cells on a large scale. Early analyses of differential …
the transcriptomes of individual cells on a large scale. Early analyses of differential …
Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis
The quantity of tumor-infiltrating lymphocytes (TILs) in breast cancer (BC) is a robust
prognostic factor for improved patient survival, particularly in triple-negative and HER2 …
prognostic factor for improved patient survival, particularly in triple-negative and HER2 …
Immune signature drives leukemia escape and relapse after hematopoietic cell transplantation
C Toffalori, L Zito, V Gambacorta, M Riba, G Oliveira… - Nature medicine, 2019 - nature.com
Transplantation of hematopoietic cells from a healthy individual (allogeneic hematopoietic
cell transplantation (allo-HCT)) demonstrates that adoptive immunotherapy can cure blood …
cell transplantation (allo-HCT)) demonstrates that adoptive immunotherapy can cure blood …
[HTML][HTML] Glutaminase inhibition impairs CD8 T cell activation in STK11-/Lkb1-deficient lung cancer
SA Best, PM Gubser, S Sethumadhavan, A Kersbergen… - Cell Metabolism, 2022 - cell.com
The tumor microenvironment (TME) contains a rich source of nutrients that sustains cell
growth and facilitate tumor development. Glucose and glutamine in the TME are essential for …
growth and facilitate tumor development. Glucose and glutamine in the TME are essential for …
[HTML][HTML] Caudovirales bacteriophages are associated with improved executive function and memory in flies, mice, and humans
J Mayneris-Perxachs, A Castells-Nobau… - Cell Host & Microbe, 2022 - cell.com
Growing evidence implicates the gut microbiome in cognition. Viruses, the most abundant
life entities on the planet, are a commonly overlooked component of the gut virome …
life entities on the planet, are a commonly overlooked component of the gut virome …
Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells
The hippocampal-entorhinal system supports cognitive functions, has lifelong neurogenic
capabilities in many species, and is selectively vulnerable to Alzheimer's disease. To …
capabilities in many species, and is selectively vulnerable to Alzheimer's disease. To …
Macrophages in bone fracture healing: their essential role in endochondral ossification
C Schlundt, T El Khassawna, A Serra, A Dienelt… - Bone, 2018 - Elsevier
In fracture healing, skeletal and immune system are closely interacting through common cell
precursors and molecular mediators. It is thought that the initial inflammatory reaction, which …
precursors and molecular mediators. It is thought that the initial inflammatory reaction, which …
SIRT1 promotes lipid metabolism and mitochondrial biogenesis in adipocytes and coordinates adipogenesis by targeting key enzymatic pathways
The NAD+-dependent deacetylase SIRT1 controls key metabolic functions by deacetylating
target proteins and strategies that promote SIRT1 function such as SIRT1 overexpression or …
target proteins and strategies that promote SIRT1 function such as SIRT1 overexpression or …