This review provides an update on the current clinical and preclinical understanding of
chemotherapy induced peripheral neuropathy (CIPN). The overview of the clinical syndrome …

Cisplatin, oxaliplatin, paclitaxel, vincristine and bortezomib are some of the most effective
drugs successfully employed (alone or in combinations) as first-line treatment for common …

Chemotherapy-induced peripheral neuropathic pain (CIPNP)—a severe adverse effect
observed in up to 80% of patients during treatment with antineoplastic drugs—limits the …

Chemotherapy induced peripheral neuropathy (CIPN) is a type of neuropathic pain that is a
major dose-limiting side-effect of potentially curative cancer chemotherapy treatment …

Anti-cancer drugs such as vincristine, paclitaxel, oxaliplatin, cisplatin and bortezomib are
well reported to exert direct and indirect effects on sensory nerves to alter the amplitude of …

Background Our previous study indicated that reactive oxygen species (ROS) are critically
involved in chronic pain. Sestrin2 (Sesn2), a novel stress-inducible protein, is evidenced to …

Paclitaxel (PTX), which is widely used in the treatment of solid tumors, leads to dose
limitation because it causes peripheral neuropathy. This study was conducted to evaluate …

Peroxynitrite (PN; ONOO−) and its reactive oxygen precursor superoxide (SO; O2•−) are
critically important in the development of pain of several etiologies including pain associated …

The mitochondrial dysfunction has a critical role in several disorders including
chemotherapy-induced peripheral neuropathies (CIPN). This is due to a related …

Chemotherapy‐induced peripheral neuropathy (CIPN) is a serious adverse side effect of
many chemotherapeutic agents, affecting> 60% of patients with cancer. Moreover, CIPN …